In silico testing of the universality of epithelial tissue growth

Jan Åström, Mikko Karttunen, Mahmood Mazarei

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
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The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the cellsim3d kinetic division model for deformable cells to investigate cell-colony scaling. With seemingly minor model changes, it can reproduce both KPZ- and MBE-like scaling in configurations that mimic the respective experiments. Tissue growth with strong cell-cell adhesion in a linear geometry is KPZ like, while weakly adhesive tissues in a radial geometry are MBE like. This result neutralizes the apparent scaling controversy.

Translated title of the contributionBestämning av universalitetsklassen för epiteltillväxt
Original languageEnglish
Article numberL062402
JournalPhysical Review E
Issue number6
Publication statusPublished - Dec 2022
MoE publication typeA1 Journal article-refereed


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