HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

MA Penttinen, CI Holmberg, Lea Sistonen, K Granfors

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    43 Citations (Scopus)


    Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.
    Original languageUndefined/Unknown
    Pages (from-to)2172–2180
    Number of pages9
    JournalArthritis and Rheumatism
    Issue number8
    Publication statusPublished - 2002
    MoE publication typeA1 Journal article-refereed

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