Abstract
Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.
Original language | Undefined/Unknown |
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Pages (from-to) | 2172–2180 |
Number of pages | 9 |
Journal | Arthritis and Rheumatism |
Volume | 46 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2002 |
MoE publication type | A1 Journal article-refereed |