HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

MA Penttinen; CI Holmberg; Lea Sistonen; K Granfors

doi:10.1002/art.10557

HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

MA Penttinen, CI Holmberg, Lea Sistonen, K Granfors

Research output: Contribution to journal › Article › Scientific › peer-review

43 Citations (Scopus)

Abstract

Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.

Original language	Undefined/Unknown
Pages (from-to)	2172–2180
Number of pages	9
Journal	Arthritis and Rheumatism
Volume	46
Issue number	8
DOIs	https://doi.org/10.1002/art.10557
Publication status	Published - 2002
MoE publication type	A1 Journal article-refereed

Access to Document

10.1002/art.10557

Cite this

@article{5d58866b91f54fa1ba0526e41c7e2aa1,

title = "HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide",

abstract = "Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.",

author = "MA Penttinen and CI Holmberg and Lea Sistonen and K Granfors",

year = "2002",

doi = "10.1002/art.10557",

language = "Odefinierat/ok{\"a}nt",

volume = "46",

pages = "2172–2180",

journal = "Arthritis and Rheumatism",

issn = "0004-3591",

publisher = "Wiley",

number = "8",

}

TY - JOUR

T1 - HLA-B27 modulates nuclear factor kappa B activation in human monocytic cells exposed to liplopolysaccharide

AU - Penttinen, MA

AU - Holmberg, CI

AU - Sistonen, Lea

AU - Granfors, K

PY - 2002

Y1 - 2002

N2 - Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.

AB - Conclusion. Our data indicate that HLA-B27 has effects on host responses to LPS that are unrelated to antigen presentation. Two crucial events in the development of arthritis, the activation of NF-kappaB and the secretion of TNFa, were found to be enhanced in HLA-B27-expressing cells upon LPS stimulation. Because LPS is known to be present in the inflamed joints of patients with reactive arthritis (ReA), the enhanced inflammatory response of HLA-B27-positive cells upon LPS stimulation offers an attractive explanation for the role of HLA-B27 in the development of ReA.

U2 - 10.1002/art.10557

DO - 10.1002/art.10557

M3 - Artikel

SN - 0004-3591

VL - 46

SP - 2172

EP - 2180

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 8

ER -