High specific activity Cu-61 via Zn-64(p,α)Cu-61 reaction at low proton energies

Stefan Thieme; Martin Walther; Stephan Preusche; Johan Rajander; Hans-Jürgen Pietzsch; Jan-Olof Lill; Michael Kaden; Olof Solin; Jörg Steinbach

doi:10.1016/j.apradiso.2012.11.007

High specific activity Cu-61 via Zn-64(p,α)Cu-61 reaction at low proton energies

Stefan Thieme
, Martin Walther
, Stephan Preusche
, Johan Rajander
, Hans-Jürgen Pietzsch
, Jan-Olof Lill
, Michael Kaden
, Olof Solin
, Jörg Steinbach

Research output: Contribution to journal › Article › Scientific › peer-review

23 Citations (Scopus)

Abstract

The PET radionuclide Cu-61 is accessible through several nuclear reactions. Besides the common production route via Ni-61(p,n)Cu-61 the Zn-64(p,alpha)Cu-61 reaction offers some advantages. Especially the comparatively cheap enriched Zn-64 makes this process economical. For fast product purification and recycling of target material an ion exchange cascade was developed. In addition a separation technique with a copper selective resin was tested. Cu-61 with specific activities up to 1000 GBq/mu mol was produced with these methods. (c) 2012 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	169–176
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	72
DOIs	https://doi.org/10.1016/j.apradiso.2012.11.007
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Keywords

Cu-61
Cyclotron
PET imaging
Targetry
Zn-64

Access to Document

10.1016/j.apradiso.2012.11.007

Cite this

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title = "High specific activity Cu-61 via Zn-64(p,α)Cu-61 reaction at low proton energies",

abstract = "The PET radionuclide Cu-61 is accessible through several nuclear reactions. Besides the common production route via Ni-61(p,n)Cu-61 the Zn-64(p,alpha)Cu-61 reaction offers some advantages. Especially the comparatively cheap enriched Zn-64 makes this process economical. For fast product purification and recycling of target material an ion exchange cascade was developed. In addition a separation technique with a copper selective resin was tested. Cu-61 with specific activities up to 1000 GBq/mu mol was produced with these methods. (c) 2012 Elsevier Ltd. All rights reserved.",

keywords = "Cu-61, Cyclotron, PET imaging, Targetry, Zn-64, Cu-61, Cyclotron, PET imaging, Targetry, Zn-64, Cu-61, Cyclotron, PET imaging, Targetry, Zn-64",

author = "Stefan Thieme and Martin Walther and Stephan Preusche and Johan Rajander and Hans-J{\"u}rgen Pietzsch and Jan-Olof Lill and Michael Kaden and Olof Solin and J{\"o}rg Steinbach",

year = "2013",

doi = "10.1016/j.apradiso.2012.11.007",

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volume = "72",

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journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - High specific activity Cu-61 via Zn-64(p,α)Cu-61 reaction at low proton energies

AU - Thieme, Stefan

AU - Walther, Martin

AU - Preusche, Stephan

AU - Rajander, Johan

AU - Pietzsch, Hans-Jürgen

AU - Lill, Jan-Olof

AU - Kaden, Michael

AU - Solin, Olof

AU - Steinbach, Jörg

PY - 2013

Y1 - 2013

N2 - The PET radionuclide Cu-61 is accessible through several nuclear reactions. Besides the common production route via Ni-61(p,n)Cu-61 the Zn-64(p,alpha)Cu-61 reaction offers some advantages. Especially the comparatively cheap enriched Zn-64 makes this process economical. For fast product purification and recycling of target material an ion exchange cascade was developed. In addition a separation technique with a copper selective resin was tested. Cu-61 with specific activities up to 1000 GBq/mu mol was produced with these methods. (c) 2012 Elsevier Ltd. All rights reserved.

AB - The PET radionuclide Cu-61 is accessible through several nuclear reactions. Besides the common production route via Ni-61(p,n)Cu-61 the Zn-64(p,alpha)Cu-61 reaction offers some advantages. Especially the comparatively cheap enriched Zn-64 makes this process economical. For fast product purification and recycling of target material an ion exchange cascade was developed. In addition a separation technique with a copper selective resin was tested. Cu-61 with specific activities up to 1000 GBq/mu mol was produced with these methods. (c) 2012 Elsevier Ltd. All rights reserved.

KW - Cu-61

KW - Cyclotron

KW - PET imaging

KW - Targetry

KW - Zn-64

KW - Cu-61

KW - Cyclotron

KW - PET imaging

KW - Targetry

KW - Zn-64

KW - Cu-61

KW - Cyclotron

KW - PET imaging

KW - Targetry

KW - Zn-64

U2 - 10.1016/j.apradiso.2012.11.007

DO - 10.1016/j.apradiso.2012.11.007

M3 - Artikel

SN - 0969-8043

VL - 72

SP - 169

EP - 176

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -