Hierarchically designed bioactive glassy nanocoatings for the growth of faster and uniformly dense apatite

Indranee Das; Samar K. Medda; De Goutam; Susanne Fagerlund; Leena Hupa; Mervi A. Puska; Pekka K. Vallittu

doi:10.1111/jace.13626

Hierarchically designed bioactive glassy nanocoatings for the growth of faster and uniformly dense apatite

Indranee Das, Samar K. Medda, De Goutam, Susanne Fagerlund, Leena Hupa, Mervi A. Puska, Pekka K. Vallittu

Laboratory of Molecular Science and Engineering

Research output: Contribution to journal › Article › Scientific › peer-review

7 Citations (Scopus)

Abstract

Crack-free bioactive nanocoatings embedded with uniformly distributed silica-rich bioactive spherical aggregates were successfully prepd. in situ by controlling the micellization of a SiO2-CaO-P2O5 sol using the tri-block copolymer P123 followed by dip-coating onto a bio-inert glass substrate and calcined. These hierarchically designed nanocoatings embedded with such bioactive glassy nanospheres (BGNS) enabled to induce the deposition of a densely populated, uniform, and well-developed needlelike cryst. carbonated hydroxyapatite coating reminiscence of the mineral phase of natural bone within a short immersion time in simulated body fluid. The BGNS nanocoatings also supported the growth and attachment of human gingival fibroblasts. The results suggest that these newly designed composite nanocoatings are noncytotoxic, capable of supporting rapid and homogeneous calcium phosphate deposition as well as subsequent crystn., and likely to be promising candidates for inert glass reinforced bone implants.

Original language	Undefined/Unknown
Pages (from-to)	2428–2437
Journal	Journal of the American Ceramic Society
Volume	98
Issue number	8
DOIs	https://doi.org/10.1111/jace.13626
Publication status	Published - 2015
MoE publication type	A1 Journal article-refereed

Access to Document

10.1111/jace.13626

http://onlinelibrary.wiley.com/doi/10.1111/jace.13626/epdf

Cite this

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title = "Hierarchically designed bioactive glassy nanocoatings for the growth of faster and uniformly dense apatite",

abstract = "Crack-free bioactive nanocoatings embedded with uniformly distributed silica-rich bioactive spherical aggregates were successfully prepd. in situ by controlling the micellization of a SiO2-CaO-P2O5 sol using the tri-block copolymer P123 followed by dip-coating onto a bio-inert glass substrate and calcined. These hierarchically designed nanocoatings embedded with such bioactive glassy nanospheres (BGNS) enabled to induce the deposition of a densely populated, uniform, and well-developed needlelike cryst. carbonated hydroxyapatite coating reminiscence of the mineral phase of natural bone within a short immersion time in simulated body fluid. The BGNS nanocoatings also supported the growth and attachment of human gingival fibroblasts. The results suggest that these newly designed composite nanocoatings are noncytotoxic, capable of supporting rapid and homogeneous calcium phosphate deposition as well as subsequent crystn., and likely to be promising candidates for inert glass reinforced bone implants.",

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AU - Das, Indranee

AU - Medda, Samar K.

AU - Goutam, De

AU - Fagerlund, Susanne

AU - Hupa, Leena

AU - Puska, Mervi A.

AU - Vallittu, Pekka K.

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AB - Crack-free bioactive nanocoatings embedded with uniformly distributed silica-rich bioactive spherical aggregates were successfully prepd. in situ by controlling the micellization of a SiO2-CaO-P2O5 sol using the tri-block copolymer P123 followed by dip-coating onto a bio-inert glass substrate and calcined. These hierarchically designed nanocoatings embedded with such bioactive glassy nanospheres (BGNS) enabled to induce the deposition of a densely populated, uniform, and well-developed needlelike cryst. carbonated hydroxyapatite coating reminiscence of the mineral phase of natural bone within a short immersion time in simulated body fluid. The BGNS nanocoatings also supported the growth and attachment of human gingival fibroblasts. The results suggest that these newly designed composite nanocoatings are noncytotoxic, capable of supporting rapid and homogeneous calcium phosphate deposition as well as subsequent crystn., and likely to be promising candidates for inert glass reinforced bone implants.

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