Heat shock factors: integrators of cell stress, development and lifespan

Malin Akerfelt, Richard I Morimoto, Lea Sistonen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

Abstract

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

Original languageEnglish
Pages (from-to)545-55
Number of pages11
JournalNature Reviews Molecular Cell Biology
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 2010
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Animals
  • Growth and Development
  • Heat-Shock Proteins/genetics
  • Humans
  • Longevity
  • Models, Biological
  • Phylogeny
  • Stress, Physiological
  • Transcription Factors/genetics

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