Heat shock factors: integrators of cell stress, development and lifespan

M Åkerfelt, RI Morimoto, Lea Sistonen

    Research output: Contribution to journalReview Article or Literature Reviewpeer-review

    804 Citations (Scopus)

    Abstract

    Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.
    Original languageUndefined/Unknown
    Pages (from-to)545–555
    Number of pages11
    JournalNature Reviews Molecular Cell Biology
    Volume11
    Issue number8
    DOIs
    Publication statusPublished - 2010
    MoE publication typeA2 Review article in a scientific journal

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