Heat shock factor 1 as a coordinator of stress and developmental pathways

J Anckar, Lea Sistonen

    Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

    136 Citations (Scopus)

    Abstract

    The transition from normal growth conditions to stressful conditions is accompanied by a robust upregulation of heat shock proteins, which dampen the cytotoxicity caused by misfolded and denatured proteins. The most prominent part of this transition occurs on the transcriptional level. In mammals, protein-damaging stress leads to the activation of heat shock factor 1(HSF1), which binds to upstream regulatory sequences in the promoters of heat shock genes. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. In addition to its established role as the main regulator of heat shock genes, new data link HSF1 to developmental pathways. In this chapter, we examine the established stress-related functions and prospect the intriguing role of HSF1 as a developmental coordinator.
    Original languageUndefined/Unknown
    Title of host publicationMolecular Aspects of the Stress Response: Chaperones, Membranes and Networks
    EditorsPeter Csermely, Laszlo Vigh
    PublisherSpringer
    Pages78–88
    ISBN (Electronic)978-0-387-39975-1
    ISBN (Print)978-0-387-39974-4
    Publication statusPublished - 2007
    MoE publication typeA3 Part of a book or another research book

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