Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Henrika Wickström; Anouk Broos; Johan Nyman; Ewelina Kortesmäki; Patrik Christoffer Eklund; Thomas de Beer; Maren Preis; Niklas Sandler; Smita Salunke; Catherine Tuleu

doi:10.1016/j.ijpharm.2017.08.036

Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Henrika Wickström, Anouk Broos, Johan Nyman, Ewelina Kortesmäki, Patrik Christoffer Eklund, Thomas de Beer, Maren Preis, Niklas Sandler, Smita Salunke (Editor), Catherine Tuleu (Editor)

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).

Original language	Undefined/Unknown
Pages (from-to)	508–509
Journal	International Journal of Pharmaceutics
Volume	536
Issue number	2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.08.036
Publication status	Published - 2018
MoE publication type	A1 Journal article-refereed

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10.1016/j.ijpharm.2017.08.036

https://www.sciencedirect.com/science/article/pii/S0378517317307433

Cite this

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title = "Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use",

abstract = " There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).",

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AU - Wickström, Henrika

AU - Broos, Anouk

AU - Nyman, Johan

AU - Kortesmäki, Ewelina

AU - Eklund, Patrik Christoffer

AU - de Beer, Thomas

AU - Preis, Maren

AU - Sandler, Niklas

A2 - Salunke, Smita

A2 - Tuleu, Catherine

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AB - There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).

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