Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Henrika Wickström; Anouk Broos; Johan Nyman; Ewelina Kortesmäki; Patrik Christoffer Eklund; Thomas de Beer; Maren Preis; Niklas Sandler; Smita Salunke; Catherine Tuleu

doi:10.1016/j.ijpharm.2017.08.036

Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

Henrika Wickström, Anouk Broos, Johan Nyman, Ewelina Kortesmäki, Patrik Christoffer Eklund, Thomas de Beer, Maren Preis, Niklas Sandler, Smita Salunke (Editor), Catherine Tuleu (Editor)

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).

Original language	Undefined/Unknown
Pages (from-to)	508–509
Journal	International Journal of Pharmaceutics
Volume	536
Issue number	2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.08.036
Publication status	Published - 2018
MoE publication type	A1 Journal article-refereed

Access to Document

10.1016/j.ijpharm.2017.08.036

https://www.sciencedirect.com/science/article/pii/S0378517317307433

Cite this

@article{8c68511d7a5746349632c16e98bb1b2c,

title = "Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use",

abstract = " There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).",

author = "Henrika Wickstr{\"o}m and Anouk Broos and Johan Nyman and Ewelina Kortesm{\"a}ki and Eklund, {Patrik Christoffer} and {de Beer}, Thomas and Maren Preis and Niklas Sandler and Smita Salunke and Catherine Tuleu",

note = "iok",

year = "2018",

doi = "10.1016/j.ijpharm.2017.08.036",

language = "Odefinierat/ok{\"a}nt",

volume = "536",

pages = "508–509",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Handheld colorimeter as quality control tool for inkjet printed flexible levothyroxine doses for pediatric use

AU - Wickström, Henrika

AU - Broos, Anouk

AU - Nyman, Johan

AU - Kortesmäki, Ewelina

AU - Eklund, Patrik Christoffer

AU - de Beer, Thomas

AU - Preis, Maren

AU - Sandler, Niklas

A2 - Salunke, Smita

A2 - Tuleu, Catherine

N1 - iok

PY - 2018

Y1 - 2018

N2 - There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).

AB - There is a need to formulate and develop age- and weight-appropriate oral dosage forms for pediatric use. The aim of this work was to manufacture flexible doses of levothyroxine (T4) on an edible bilayered substrate using inkjet technology. The use of a handheld colorimeter as a quality control tool, to differentiate between doses with different color intensities, was also studied. The need for orally dissolvable T4 formulations was addressed in the Best Pharmaceuticals for Children Act (BPCA) Priority List of Needs in Pediatric Therapeutics of the National Health Institution of the United States (BPCA, 2012).

U2 - 10.1016/j.ijpharm.2017.08.036

DO - 10.1016/j.ijpharm.2017.08.036

M3 - Artikel

SN - 0378-5173

VL - 536

SP - 508

EP - 509

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 2

ER -