Global SUMOylation on active chromatin is an acute heat stress response restricting transcription

EA Niskanen; M Malinen; P Sutinen; S Toropainen; V Paakinaho; Johanna Vihervaara; Jenny Joutsen; MU Kaikkonen; Lea Sistonen; JJ Palvimo

doi:10.1186/s13059-015-0717-y

Global SUMOylation on active chromatin is an acute heat stress response restricting transcription

EA Niskanen, M Malinen, P Sutinen, S Toropainen, V Paakinaho, Johanna Vihervaara, Jenny Joutsen, MU Kaikkonen, Lea Sistonen, JJ Palvimo

Cell Biology

Research output: Contribution to journal › Article › Scientific › peer-review

63 Citations (Scopus)

Abstract

Conclusions: HS-triggered SUMOylation targets promoters and enhancers of actively transcribed genes where it restricts the transcriptional activity of the HS-induced genes. PIAS1-mediated promoter SUMOylation is likely to regulate Pol2-associated factors in HS.

Original language	Undefined/Unknown
Pages (from-to)	1–19
Number of pages	19
Journal	GENOME BIOLOGY
Volume	16
DOIs	https://doi.org/10.1186/s13059-015-0717-y
Publication status	Published - 2015
MoE publication type	A1 Journal article-refereed

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10.1186/s13059-015-0717-y

Cite this

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title = "Global SUMOylation on active chromatin is an acute heat stress response restricting transcription",

abstract = "Conclusions: HS-triggered SUMOylation targets promoters and enhancers of actively transcribed genes where it restricts the transcriptional activity of the HS-induced genes. PIAS1-mediated promoter SUMOylation is likely to regulate Pol2-associated factors in HS.",

author = "EA Niskanen and M Malinen and P Sutinen and S Toropainen and V Paakinaho and Johanna Vihervaara and Jenny Joutsen and MU Kaikkonen and Lea Sistonen and JJ Palvimo",

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T1 - Global SUMOylation on active chromatin is an acute heat stress response restricting transcription

AU - Niskanen, EA

AU - Malinen, M

AU - Sutinen, P

AU - Toropainen, S

AU - Paakinaho, V

AU - Vihervaara, Johanna

AU - Joutsen, Jenny

AU - Kaikkonen, MU

AU - Sistonen, Lea

AU - Palvimo, JJ

PY - 2015

Y1 - 2015

N2 - Conclusions: HS-triggered SUMOylation targets promoters and enhancers of actively transcribed genes where it restricts the transcriptional activity of the HS-induced genes. PIAS1-mediated promoter SUMOylation is likely to regulate Pol2-associated factors in HS.

AB - Conclusions: HS-triggered SUMOylation targets promoters and enhancers of actively transcribed genes where it restricts the transcriptional activity of the HS-induced genes. PIAS1-mediated promoter SUMOylation is likely to regulate Pol2-associated factors in HS.

U2 - 10.1186/s13059-015-0717-y

DO - 10.1186/s13059-015-0717-y

M3 - Artikel

SN - 1474-7596

VL - 16

SP - 1

EP - 19

JO - GENOME BIOLOGY

JF - GENOME BIOLOGY

ER -