Future and the past of polymeric antioxidants

Sergey K. Filippov; Nina Domnina; Violetta Vol'eva

doi:10.1002/pat.5203

Future and the past of polymeric antioxidants

Sergey K. Filippov^*, Nina Domnina, Violetta Vol'eva

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Review Article or Literature Review › peer-review

4 Citations (Scopus)

Abstract

Hybrid macromolecular antioxidants has evolved into a mature research field last three decades. The main concept of this area was to design polymer conjugates that combine in one structure the hydrophilic properties of a polymer backbone and biological efficiency of hydrophobic antioxidants. Over the years, the understanding of different aspects of such approach has grown. In general, meticulous selection of each component is essential to obtain the conjugate with required properties. This review overview a plethora of hybrid macromolecular antioxidants synthesized over the last 20 years, together with the discussion their physicochemical properties and application for biomedical purposes.

Original language	English
Pages (from-to)	2655-2668
Number of pages	14
Journal	Polymers for Advanced Technologies
Volume	32
Issue number	7
DOIs	https://doi.org/10.1002/pat.5203
Publication status	Published - Jul 2021
MoE publication type	A2 Review article in a scientific journal

Keywords

amphiphilic polymers
hybrid macromolecular antioxidants
mechanism of antioxidant activity
sterically hindered phenols
structure

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10.1002/pat.5203

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title = "Future and the past of polymeric antioxidants",

abstract = "Hybrid macromolecular antioxidants has evolved into a mature research field last three decades. The main concept of this area was to design polymer conjugates that combine in one structure the hydrophilic properties of a polymer backbone and biological efficiency of hydrophobic antioxidants. Over the years, the understanding of different aspects of such approach has grown. In general, meticulous selection of each component is essential to obtain the conjugate with required properties. This review overview a plethora of hybrid macromolecular antioxidants synthesized over the last 20 years, together with the discussion their physicochemical properties and application for biomedical purposes.",

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author = "Filippov, {Sergey K.} and Nina Domnina and Violetta Vol'eva",

note = "Funding Information: The authors thank all Master and PhD students, employees, and faculty staff of Saint‐Petersburg State University, Department of Chemistry, Chair of Polymer Chemistry for their help and support. Sergey Filippov acknowledges the financial support of the grant BR05236446 from the Ministry of Science (Republic of Kazakhstan). Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd",

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AU - Filippov, Sergey K.

AU - Domnina, Nina

AU - Vol'eva, Violetta

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N2 - Hybrid macromolecular antioxidants has evolved into a mature research field last three decades. The main concept of this area was to design polymer conjugates that combine in one structure the hydrophilic properties of a polymer backbone and biological efficiency of hydrophobic antioxidants. Over the years, the understanding of different aspects of such approach has grown. In general, meticulous selection of each component is essential to obtain the conjugate with required properties. This review overview a plethora of hybrid macromolecular antioxidants synthesized over the last 20 years, together with the discussion their physicochemical properties and application for biomedical purposes.

AB - Hybrid macromolecular antioxidants has evolved into a mature research field last three decades. The main concept of this area was to design polymer conjugates that combine in one structure the hydrophilic properties of a polymer backbone and biological efficiency of hydrophobic antioxidants. Over the years, the understanding of different aspects of such approach has grown. In general, meticulous selection of each component is essential to obtain the conjugate with required properties. This review overview a plethora of hybrid macromolecular antioxidants synthesized over the last 20 years, together with the discussion their physicochemical properties and application for biomedical purposes.

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KW - sterically hindered phenols

KW - structure

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Future and the past of polymeric antioxidants

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