Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development

Deepa Nakmode, Valamla Bhavana, Pradip Thakor, Jitender Madan, Pankaj Kumar Singh, Shashi Bala Singh, Jessica M. Rosenholm, Kuldeep K. Bansal, Neelesh Kumar Mehra

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

9 Citations (Scopus)
78 Downloads (Pure)


Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants eliminate the dissolution/dissolving step, which is likely to be the rate-limiting factor for oral absorption of poorly water-soluble drugs. In this review, we exhaustively summarize the lipids excipients in relation to their classification, absorption mechanisms, and lipid-based product development. Methodologies utilized for the preparation of solid and semi-solid lipid formulations, applications, phase behaviour, and regulatory perspective of lipid excipients are discussed.
Original languageEnglish
Article number831
Number of pages28
Issue number4
Publication statusPublished - 11 Apr 2022
MoE publication typeA2 Review article in a scientific journal


  • Lipid based drug delivery systems
  • bioavailability
  • Poorly soluble drugs
  • oral drug administration
  • computational modeling
  • lipid excipients
  • oral absorption
  • lipid-based nanosystems
  • Poorly water-soluble drugs


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