Fast and efficient copper-mediated 18F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying

Salla Orvokki Lahdenpohja, Noora Annika Rajala, Johan Rajander, Anna Kaarina Kirjavainen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Copper-mediated radiofluorination is a straightforward method to produce a variety of [18F]fluoroarenes and [18F]fluoroheteroarenes. To minimize the number of steps in the production of 18F-labelled radiopharmaceuticals, we have developed a short and efficient azeotropic drying-free 18F-labelling method using copper-mediated fluorination. Our goal was to improve the copper-mediated method to achieve wide substrate scope with good radiochemical yields with short synthesis time.

Original languageUndefined/Unknown
Pages (from-to)
JournalEJNMMI Radiopharmacy and Chemistry
Volume4
DOIs
Publication statusPublished - 2019
MoE publication typeA1 Journal article-refereed

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