TY - JOUR
T1 - Facile Fabrication of Cellulose Nanofibrils/Chitosan Beads as the Potential pH-Sensitive Drug Carriers
AU - Wu, Meiyan
AU - Deng, Wangfang
AU - Zhang, Yidong
AU - Chen, Chao
AU - Liu, Zhexuan
AU - Fatehi, Pedram
AU - Li, Bin
N1 - Funding Information:
Funding: This work was financially supported by Shandong Provincial Natural Science Foundation for DistinguishedYoung Scholars(China) (Grant No.ZR2019JQ10),andQingdao independent innovation major project (Grant No.21-1-2-23-hz).
Funding Information:
Funding: This work was financially supported by Shandong Provincial Natural Science Foundation Author Contributions:M.W., investigation and writing-original draft preparation; W.D.,investiga-tionandmethodology;Y.Z.,investigation;C.C., investigation;Z.L., investigation;P.F.,methodology,writing-reviewing & editing;B.L., project administration, supervision, writing-reviewing & editing. All authors have read and agreed to the published version of the manuscript.
Funding Information:
This work was financially supported by Shandong Provincial Natural Science Foundation for Distinguished Young Scholars (China) (Grant No. ZR2019JQ10), and Qingdao independent innovation major project (Grant No. 21-1-2-23-hz).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/4
Y1 - 2022/6/4
N2 - It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.
AB - It is highly desirable to develop a safe, highly efficient, and biodegradable drug carrier with an enhanced drug transport efficiency. Cellulose nanofibrils (CNF) and chitosan (CS) composite hydrogels are promising candidate carriers with biological compatibility and non-cytotoxicity. Herein, the CNF/CS composite beads were prepared by dissolving cellulose and CS in LiBr molten salt hydrate and regenerating in ethanol. This preparation method is facile and efficient, and the obtained porous CNF/CS beads with the weight ratio of 8:2 exhibited a large specific surface area, uniform micro-nano-sized pores, strong mechanical property, and water absorption-resistance. Moreover, these beads as drug (tetracycline hydrochloride, TH) carriers showed a higher encapsulation efficiency (47.4%) at the TH concentration of 5 mg/mL in 24 h, and a higher drug loading rate (12.0%) than pure CNF and other CNF/CS beads prepared with different ratios. In addition, the TH releasing behavior of CNF/CS (8:2) beads fitted well into the zero-order, first-order, and Higuchi models under an acid condition, indicating that the drug release of these pH-sensitive beads was mainly affected by drug concentration under an acid condition. Therefore, these CNF/CS beads have great potential to be used as drug carriers for medical applications.
KW - cellulose nanofibrils
KW - chitosan
KW - drug carrier
KW - drug release
KW - tetracycline hydrochloride
UR - http://www.scopus.com/inward/record.url?scp=85131853576&partnerID=8YFLogxK
U2 - 10.3390/polym14112286
DO - 10.3390/polym14112286
M3 - Article
AN - SCOPUS:85131853576
SN - 2073-4360
VL - 14
JO - Polymers
JF - Polymers
IS - 11
M1 - 2286
ER -