Fabricated technology of biomedical micro-nano hydrogel

Shu Yang, Fan Wang, Huijie Han, Hélder A. Santos, Yu Zhang, Hongbo Zhang, Jie Wei, zhengwei cai

Research output: Contribution to journalArticleScientificpeer-review

28 Citations (Scopus)
60 Downloads (Pure)


Micro-nano hydrogel is a novel functional material that has attracted extensive attention in various fields. Due to the size of micron and nano level, high water content and high specific surface area, the micro-nano hydrogels can achieve minimally invasive repair and are considered as promising agents in tissue repair engineering. In this review, we summarize the design and development of micro-nano hydrogels for biomedical applications, first introduce biopolymers for the synthesis of hydrogels, then introduce the preparation technologies of microgels and nanogels respectively, and systematically summarize the application characteristics and forms of different preparation technologies. Finally, the latest application progresses of microgels in local drug delivery, bone tissue repair, soft tissue repair and immunomodulation are introduced in detail, as well as the latest application progress of nanohydrogels in cartilage repair, antibacterial, antitumor/cancer nerve repair and prevention and diagnosis of diseases, and the key research directions of micro-nano hydrogel preparation technologies in the future are clarified.
Original languageEnglish
Pages (from-to)31-48
JournalBiomedical Technology
Publication statusPublished - Jun 2023
MoE publication typeA1 Journal article-refereed


  • hydrogel
  • biopolymers
  • microgels
  • nanogels
  • tissue engineering


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