Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era

Didem Sen Karaman, Utku Kürşat Ercan, Emel Bakay, Nermin Topaloğlu, Jessica Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

12 Citations (Scopus)
27 Downloads (Pure)

Abstract

The threats posed by the impending “postantibiotic era” have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic changes. With very few new antibiotics in the drug development pipeline, not being able to match the pace of antimicrobial resistance evolution, developments within other fields such as materials sciences and medical technologies are required to realize innovative antibacterial approaches. This progress report presents recent advances in especially nanotechnology-based approaches and their concomitant use with complementary antibacterial treatments. Synergistically improved antibacterial activity can be reached by considering novel, promising approaches such as photodynamic and photothermal therapy as well as cold atmospheric pressure treatments as complementary strategies to fight against antibacterial resistance. Moreover, this report describes how these novel technologies can be further improved especially by integration of nanomaterials into the currently applied single modal strategies against bacterial infections.
Original languageEnglish
Article number1908783
Pages (from-to)
JournalAdvanced Functional Materials
Volume30
Issue number15
DOIs
Publication statusPublished - 13 Feb 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • antibiotic resistance
  • Antimicrobial resistance (AMR)

Fingerprint

Dive into the research topics of 'Evolving Technologies and Strategies for Combating Antibacterial Resistance in the Advent of the Postantibiotic Era'. Together they form a unique fingerprint.

Cite this