Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

AS Sahlberg, MA Penttinen, KM Heiskanen, RA Colbert, Lea Sistonen, K Granfors

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    17 Citations (Scopus)

    Abstract

    Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.
    Original languageUndefined/Unknown
    Pages (from-to)2652–2662
    Number of pages11
    JournalArthritis and Rheumatism
    Volume56
    Issue number8
    DOIs
    Publication statusPublished - 2007
    MoE publication typeA1 Journal article-refereed

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