Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

AS Sahlberg; MA Penttinen; KM Heiskanen; RA Colbert; Lea Sistonen; K Granfors

doi:10.1002/art.22746

Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding

AS Sahlberg, MA Penttinen, KM Heiskanen, RA Colbert, Lea Sistonen, K Granfors

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.

Original language	Undefined/Unknown
Pages (from-to)	2652–2662
Number of pages	11
Journal	Arthritis and Rheumatism
Volume	56
Issue number	8
DOIs	https://doi.org/10.1002/art.22746
Publication status	Published - 2007
MoE publication type	A1 Journal article-refereed

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10.1002/art.22746

Cite this

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title = "Evidence that the p38 MAP kinase pathway is dysregulated in HLA-B27-expressing human monocytic cells - Correlation with HLA-B27 misfolding",

abstract = "Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.",

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AU - Sahlberg, AS

AU - Penttinen, MA

AU - Heiskanen, KM

AU - Colbert, RA

AU - Sistonen, Lea

AU - Granfors, K

PY - 2007

Y1 - 2007

N2 - Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.

AB - Conclusion. Our results show that p38 activity plays a crucial role in controlling intracellular S enteritidis in U937 cells. Enhanced replication of bacteria in B27-expressing cells requires that the HCs contain glutamic acid at position 45 and cysteine at position 67. Furthermore, in transfectants expressing misfolded B27 HCs, p38 inhibition had no significant effect on bacterial replication, suggesting that in these cells, the p38 pathway may not function properly.

U2 - 10.1002/art.22746

DO - 10.1002/art.22746

M3 - Artikel

SN - 0004-3591

VL - 56

SP - 2652

EP - 2662

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 8

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