Evaluation of the wound healing and anti-inflammatory activities and phytochemical analysis of Myrtus communis L.

Ibrahim Tumen, Esra Kupeli Akkol, Ipek Suntar, Guler Erbey, Mehmet Kurtca, Hikmet Keles, Markku Reunanen, Andrey Pranovich

Research output: Contribution to journalArticleScientificpeer-review


This study evaluates wound healing activities of n-hexane and acetone extracts, as well as the essential oils obtained from the berries and leaves of Myrtus communis L., (Myrtaceae), using excision and incision wound models. Ulcerations of the skin tissues, re-epithelization, fibroblast proliferation, mono/polymorphonuclear cells, vascularization and collagen increase were qualitatively evaluated by the histopathological analysis. An acute anti-inflammatory activity method based on the inhibition of the increase in vascular permeability was used to determine the anti-inflammatory effect of the extracts and essential oils. Oils' yields and chemical profiles were also determined. Volatile oil, obtained from M. communis berries, provided a contraction rate of 60.08% in the circular excision wound model and a tensile strength ratio of 39.1% in the linear incision wound model. The n-hexane extract of M. communis berries was found to possess significant activity in the circular excision wound model with a ratio of 49.2%. However, it did not provide a significant increase in wound tensile strength. Berries' essential oils provided significant inhibition (28.5%). Particularly the essential oil of M. communis berries and its extracts can be used wound healing and anti-inflammatory purposes.
Original languageUndefined/Unknown
Pages (from-to)4420–4428
Number of pages9
JournalFresenius Environmental Bulletin
Issue number7
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed


  • Myrtus communis
  • anti-inflammatory
  • Myrtaceae
  • essential oil

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