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Abstract
Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus ® and poly(lactide) copolymer. The presence of “ene” groups on PJL’s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and phenyl groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.
| Original language | English |
|---|---|
| Number of pages | 9 |
| Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
| DOIs | |
| Publication status | E-pub ahead of print - 8 Jul 2022 |
| MoE publication type | A1 Journal article-refereed |
Keywords
- polymer
- functional polymer
- polymeric micelles
- aqueous solubility
- renewable polymers
- non-covalent interactions
- polymer-drug interactions
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Dive into the research topics of 'Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers'. Together they form a unique fingerprint.Projects
- 1 Finished
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Jasmine PRO: A versatile platform for drug delivery
Rosenholm, J. (Principal Investigator), Wilen, C.-E. (Co-Principal Investigator), Soidinsalo, S. (Co-Principal Investigator), Bansal, K. (Co-Investigator) & Monaco, E. (Co-Investigator)
01/09/21 → 31/05/24
Project: Industry/Business Finland
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