Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers

Kuldeep Kumar Bansal, Aliaa A. Ali, Mijanur Rahman, Erica Sjöholm, Carl-Eric Wilén, Jessica M. Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)
67 Downloads (Pure)

Abstract

Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus ® and poly(lactide) copolymer. The presence of “ene” groups on PJL’s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and phenyl groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.

Original languageEnglish
Number of pages9
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
DOIs
Publication statusE-pub ahead of print - 8 Jul 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • polymer
  • functional polymer
  • polymeric micelles
  • aqueous solubility
  • renewable polymers
  • non-covalent interactions
  • polymer-drug interactions

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