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Abstract
Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus ® and poly(lactide) copolymer. The presence of “ene” groups on PJL’s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and phenyl groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.
Original language | English |
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Number of pages | 9 |
Journal | International Journal of Polymeric Materials and Polymeric Biomaterials |
DOIs | |
Publication status | E-pub ahead of print - 8 Jul 2022 |
MoE publication type | A1 Journal article-refereed |
Keywords
- polymer
- functional polymer
- polymeric micelles
- aqueous solubility
- renewable polymers
- non-covalent interactions
- polymer-drug interactions
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Dive into the research topics of 'Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers'. Together they form a unique fingerprint.Projects
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Jasmine PRO: A versatile platform for drug delivery
Rosenholm, J., Wilen, C., Soidinsalo, S., Bansal, K. & Monaco, E.
01/09/21 → 31/05/24
Project: Industry/Business Finland
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