Evaluation of mesoporous TCPSi, MCM-41, SBA-15, and TUD-1 materials as API carriers for oral drug delivery

T. Heikkilä, J. Salonen, J. Tuura, N. Kumar, T. Salmi, D. Yu Murzin, M. S. Hamdy, G. Mul, L. Laitinen, A. M. Kaukonen, J. Hirvonen, V. P. Lehto*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

141 Citations (Scopus)

Abstract

The feasibility of four mesoporous materials composed of biocompatible Si (TCPSi) or SiO2 (MCM-41, SBA-15, and TUD-1) were evaluated for oral drug delivery applications. The main focus was to study the effect of the materials different pore systems (unidirectional/2D/3D) and their pore diameters, pore size distributions, pore volumes on the maximal drug load capacity, and release profiles of a loaded active pharmaceutical ingredient. Ibuprofen was used as the model drug. The total pore volume of the mesoporous solid was the main factor limiting the maximum drug load capacity, with SBA-15 reaching a very high drug load of 1:1 in weight due to its high pore volume. Dissolution experiments were performed in HBSS buffers of pH 5.5, 6.8, and 7.4 to mimic the conditions in the small intestine. At pH 5.5 the dissolution rate of ibuprofen released from the mesoporous carriers was significantly faster compared with the standard bulk ibuprofen (86-63% versus 25% released at 45 min), with the fastest release observed from the 3D pore network of TUD-1 carrier. The utilization of mesoporous carriers diminished the pH dependency of ibuprofen dissolution (pKa = 4.42), providing an interesting prospect for the formulation of poorly soluble drug compounds.

Original languageEnglish
Pages (from-to)337-347
Number of pages11
JournalDrug Delivery
Volume14
Issue number6
DOIs
Publication statusPublished - Aug 2007
MoE publication typeA1 Journal article-refereed

Keywords

  • Dissolution Enhancement
  • Drug Delivery
  • Drug Loading
  • Drug Release
  • Mesoporous Materials

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