Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans

Kaarina Ranta; Kaisa Nieminen; Filip S. Ekholm; Moniká Poláková; Mattias U.Roslund [Unknown]; Tiina Saloranta; Reko Leino; Johannes Savolainen

doi:10.1128/CVI.00298-12

Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans

Kaarina Ranta, Kaisa Nieminen, Filip S. Ekholm, Moniká Poláková, Mattias U.Roslund [Unknown], Tiina Saloranta, Reko Leino, Johannes Savolainen

Research output: Contribution to journal › Article › Scientific › peer-review

25 Citations (Scopus)

Abstract

Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).

Original language	Undefined/Unknown
Pages (from-to)	1889–1893
Number of pages	5
Journal	Clinical and Vaccine Immunology
Volume	19
Issue number	11
DOIs	https://doi.org/10.1128/CVI.00298-12
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

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10.1128/CVI.00298-12

Cite this

Ranta, K., Nieminen, K., Ekholm, F. S., Poláková, M., [Unknown], M. U. R., Saloranta, T., Leino, R., & Savolainen, J. (2012). Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans. Clinical and Vaccine Immunology, 19(11), 1889–1893. https://doi.org/10.1128/CVI.00298-12

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abstract = "Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).",

author = "Kaarina Ranta and Kaisa Nieminen and Ekholm, {Filip S.} and Monik{\'a} Pol{\'a}kov{\'a} and [Unknown], {Mattias U.Roslund} and Tiina Saloranta and Reko Leino and Johannes Savolainen",

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Ranta, K, Nieminen, K, Ekholm, FS, Poláková, M, [Unknown], MUR, Saloranta, T , Leino, R & Savolainen, J 2012, 'Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans', Clinical and Vaccine Immunology, vol. 19, no. 11, pp. 1889–1893. https://doi.org/10.1128/CVI.00298-12

Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans. / Ranta, Kaarina; Nieminen, Kaisa; Ekholm, Filip S. et al.
In: Clinical and Vaccine Immunology, Vol. 19, No. 11, 2012, p. 1889–1893.

Research output: Contribution to journal › Article › Scientific › peer-review

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AB - Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).

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DO - 10.1128/CVI.00298-12

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