Evaluation of Immunostimulatory Activities of Synthetic Mannose-Containing Structures Mimicking the beta-(1 -> 2)-Linked Cell Wall Mannans of Candida albicans

Kaarina Ranta, Kaisa Nieminen, Filip S. Ekholm, Moniká Poláková, Mattias U.Roslund [Unknown], Tiina Saloranta, Reko Leino, Johannes Savolainen

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    Abstract

    Immunostimulatory properties of synthetic structures mimicking the beta-(1 -> 2)-linked mannans of Candida albicans were evaluated in vitro. Contrary to earlier observations, tumor necrosis factor (TNF) production was not detected after stimulation with mannotetraose in mouse macrophages. Divalent disaccharide 1,4-bis(alpha-D-mannopyranosyloxy) butane induced TNF and some molecules induced low levels of gamma interferon (IFN-gamma) in human peripheral blood mononuclear cells (PBMC).
    Original languageUndefined/Unknown
    Pages (from-to)1889–1893
    Number of pages5
    JournalClinical and Vaccine Immunology
    Volume19
    Issue number11
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

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