Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

Sanni Tuominen, Thomas Keller, Natalia Petruk, Francisco López-Picón, Dominik Eichin, Eliisa Löyttyniemi, Alejandra Verhassel , Johan Rajander, Jouko Sandholm , Johanna Tuomela, Tove J Grönroos

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).
Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
DOIs
Publication statusPublished - 19 Dec 2020
MoE publication typeA1 Journal article-refereed

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