Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

Sanni Tuominen; Thomas Keller; Natalia Petruk; Francisco López-Picón; Dominik Eichin; Eliisa Löyttyniemi; Alejandra  Verhassel; Johan Rajander; Jouko Sandholm; Johanna Tuomela; Tove J  Grönroos

doi:10.1007/s00259-020-05115-z

Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

Sanni Tuominen, Thomas Keller, Natalia Petruk, Francisco López-Picón, Dominik Eichin, Eliisa Löyttyniemi, Alejandra Verhassel , Johan Rajander, Jouko Sandholm , Johanna Tuomela, Tove J Grönroos

Turku PET Centre

Research output: Contribution to journal › Article › Scientific › peer-review

1 Citation (Scopus)

Abstract

Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).

Original language	English
Journal	European Journal of Nuclear Medicine and Molecular Imaging
DOIs	https://doi.org/10.1007/s00259-020-05115-z
Publication status	Published - 19 Dec 2020
MoE publication type	A1 Journal article-refereed

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Tuominen, S., Keller, T., Petruk, N., López-Picón, F., Eichin, D., Löyttyniemi, E., Verhassel , A., Rajander, J., Sandholm , J., Tuomela, J., & Grönroos, T. J. (2020). Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy. European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-020-05115-z

Tuominen, Sanni ; Keller, Thomas ; Petruk, Natalia ; López-Picón, Francisco ; Eichin, Dominik ; Löyttyniemi, Eliisa ; Verhassel , Alejandra ; Rajander, Johan ; Sandholm , Jouko ; Tuomela, Johanna ; Grönroos, Tove J . / Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy. In: European Journal of Nuclear Medicine and Molecular Imaging. 2020.

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title = "Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy",

abstract = "Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).",

author = "Sanni Tuominen and Thomas Keller and Natalia Petruk and Francisco L{\'o}pez-Pic{\'o}n and Dominik Eichin and Eliisa L{\"o}yttyniemi and Alejandra Verhassel and Johan Rajander and Jouko Sandholm and Johanna Tuomela and Gr{\"o}nroos, {Tove J}",

year = "2020",

month = dec,

day = "19",

doi = "10.1007/s00259-020-05115-z",

language = "English",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

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Tuominen, S, Keller, T, Petruk, N, López-Picón, F, Eichin, D, Löyttyniemi, E, Verhassel , A, Rajander, J, Sandholm , J, Tuomela, J & Grönroos, TJ 2020, 'Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy', European Journal of Nuclear Medicine and Molecular Imaging. https://doi.org/10.1007/s00259-020-05115-z

Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy. / Tuominen, Sanni; Keller, Thomas; Petruk, Natalia; López-Picón, Francisco; Eichin, Dominik; Löyttyniemi, Eliisa; Verhassel , Alejandra ; Rajander, Johan; Sandholm , Jouko; Tuomela, Johanna; Grönroos, Tove J .

In: European Journal of Nuclear Medicine and Molecular Imaging, 19.12.2020.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy

AU - Tuominen, Sanni

AU - Keller, Thomas

AU - Petruk, Natalia

AU - López-Picón, Francisco

AU - Eichin, Dominik

AU - Löyttyniemi, Eliisa

AU - Verhassel , Alejandra

AU - Rajander, Johan

AU - Sandholm , Jouko

AU - Tuomela, Johanna

AU - Grönroos, Tove J

PY - 2020/12/19

Y1 - 2020/12/19

N2 - Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).

AB - Many malignant tumours have increased TSPO expression, which has been related to a poor prognosis. TSPO-PET tracers have not comprehensively been evaluated in peripherally located tumours. This study aimed to evaluate whether N,N-diethyl-2-(2-(4-([18F]fluoro)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide ([18F]F-DPA) can reflect radiotherapy (RT)-induced changes in TSPO activity in head and neck squamous cell carcinoma (HNSCC).

U2 - 10.1007/s00259-020-05115-z

DO - 10.1007/s00259-020-05115-z

M3 - Article

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

ER -