Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina; Eleonora Macchia; Angelo Tricase; Cecilia Scandurra; Anna Imbriano; Fabrizio Torricelli; Nicola Cioffi; Luisa Torsi; Paolo Bollella

doi:10.1002/elsa.202100216

Enzyme based field effect transistor: State-of-the-art and future perspectives

Lucia Sarcina
, Eleonora Macchia
, Angelo Tricase
, Cecilia Scandurra
, Anna Imbriano
, Fabrizio Torricelli
, Nicola Cioffi
, Luisa Torsi^*
, Paolo Bollella^*

^*Corresponding author for this work

Physics

Research output: Contribution to journal › Short survey › peer-review

24 Citations (Scopus)

85 Downloads (Pure)

Abstract

The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

Original language	English
Article number	e2100216
Journal	Electrochemical Science Advances
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/elsa.202100216
Publication status	Published - Jun 2023
MoE publication type	O2 Other

Funding

Lucia Sarcina and Eleonora Macchia contributed equally to this work. The following funding agencies are acknowledged: Academy of Finland projects #316881, #316883 ‘‘Spatiotemporal control of Cell Functions’’, #332106 “ProSiT—Protein Detection at the Single‐Molecule Limit with a Self‐powered Organic Transistor for HIV early diagnosis”; Biosensori analitici usa‐e getta a base di transistori organici auto‐alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell'HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR‐FSE 2014/2020; Dottorati innovativi con caratterizzazione industrial—PON R&I 2014–2020; “Sensore bio‐elettronico usa‐e‐getta per l'HIV autoalimentato da una cella a combustibile biologica” (BioElSens&Fuel); SiMBiT—Single molecule bio‐electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB—Sviluppo di piattaforme meccatroniche, genomiche e bioinformatiche per l'oncologia di precisione—ARS01_01195‐PON “RICERCA E INNOVAZIONE” 2014–2020; Åbo Akademi University CoE “Bioelectronic activation of cell functions”; and CSGI are acknowledged for partial financial support.

Keywords

enzymes
extended gate configuration
field-effect transistors
modified electrodes
potentiometric sensors

Access to Document

10.1002/elsa.202100216Licence: CC BY

Electrochemical Science Adv - 2022 - Sarcina - Enzyme based field effect transistor State‐of‐the‐art and futureFinal published version, 2.22 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202401314929

Cite this

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title = "Enzyme based field effect transistor: State-of-the-art and future perspectives",

abstract = "The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices{\textquoteright} configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.",

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AU - Sarcina, Lucia

AU - Macchia, Eleonora

AU - Tricase, Angelo

AU - Scandurra, Cecilia

AU - Imbriano, Anna

AU - Torricelli, Fabrizio

AU - Cioffi, Nicola

AU - Torsi, Luisa

AU - Bollella, Paolo

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AB - The review discloses the historical and technological evolution of enzyme-based field-effect transistors (EnFETs) underlying the importance of gate electrode modification toward the implementation of novel FETs configurations such as extended-gate FET (EG-FETs) or EG organic FETs (EG-OFETs). The working principle of the EnFETs as postulated by Bergveld in 1970, who defined the EnFET as an ion-selective FET (ISFET) modified with enzyme-membrane, is also discussed considering the analytical equations related to the EnFET output response. For each category, namely EnFETs, EG-FETs, and EG-OFETs, we reviewed the key devices’ configurations that addressed the research in this field in the last 40 years with particular attention to the analytical figures of merit.

KW - enzymes

KW - extended gate configuration

KW - field-effect transistors

KW - modified electrodes

KW - potentiometric sensors

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Enzyme based field effect transistor: State-of-the-art and future perspectives

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