Abstract
In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.
| Original language | English |
|---|---|
| Article number | 2418 |
| Number of pages | 37 |
| Journal | Microorganisms |
| Volume | 10 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 6 Dec 2022 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
This research was supported by the Science Fund of the Republic of Serbia, #7726976, Integrated Strategy for Rehabilitation of Disturbed Land Surfaces and Control of Air Pollution–RECAP. The authors acknowledge financial support of the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. 451-03-68/2022-14/200125, 451-03-68/2022-14/200287).