Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27

MA Penttinen, KM Heiskanen, R Mohapatra, ML DeLay, RA Colbert, Lea Sistonen, K Granfors

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    Abstract

    Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.
    Original languageUndefined/Unknown
    Pages (from-to)2255–2263
    Number of pages9
    JournalArthritis and Rheumatism
    Volume50
    Issue number7
    DOIs
    Publication statusPublished - 2004
    MoE publication typeA1 Journal article-refereed

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