Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27

MA Penttinen; KM Heiskanen; R Mohapatra; ML DeLay; RA Colbert; Lea Sistonen; K Granfors

doi:10.1002/art.20336

Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27

MA Penttinen, KM Heiskanen, R Mohapatra, ML DeLay, RA Colbert, Lea Sistonen, K Granfors

Research output: Contribution to journal › Article › Scientific › peer-review

59 Citations (Scopus)

Abstract

Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.

Original language	Undefined/Unknown
Pages (from-to)	2255–2263
Number of pages	9
Journal	Arthritis and Rheumatism
Volume	50
Issue number	7
DOIs	https://doi.org/10.1002/art.20336
Publication status	Published - 2004
MoE publication type	A1 Journal article-refereed

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10.1002/art.20336

Cite this

@article{3b28b501aef346ad8aa296d39eb251d5,

title = "Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27",

abstract = "Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.",

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Penttinen, MA, Heiskanen, KM, Mohapatra, R, DeLay, ML, Colbert, RA, Sistonen, L & Granfors, K 2004, 'Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27', Arthritis and Rheumatism, vol. 50, no. 7, pp. 2255–2263. https://doi.org/10.1002/art.20336

Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27. / Penttinen, MA; Heiskanen, KM; Mohapatra, R et al.

In: Arthritis and Rheumatism, Vol. 50, No. 7, 2004, p. 2255–2263.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells - Dependency on glutamic acid at position 45 in the B pocket of HLA-B27

AU - Penttinen, MA

AU - Heiskanen, KM

AU - Mohapatra, R

AU - DeLay, ML

AU - Colbert, RA

AU - Sistonen, Lea

AU - Granfors, K

PY - 2004

Y1 - 2004

N2 - Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.

AB - Conclusion. Our data indicate that HLA-1327 expression modulates the host-microbe interaction that results in an impaired capacity of monocytes to resist intracellular replication of S enteritidis. The phenotype is dependent on glutamic acid at position 45 in the B pocket and, thus, may be due to properties of the B27 heavy chain that are related to this residue. The ability of HLA-B27 to confer susceptibility to Salmonella-triggered reactive arthritis may occur, at least in part, through these modulatory effects.

U2 - 10.1002/art.20336

DO - 10.1002/art.20336

M3 - Artikel

SN - 0004-3591

VL - 50

SP - 2255

EP - 2263

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

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