Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer; Sami Sanlidag; Carlijn V.C. Bouten; Cecilia Sahlgren

doi:10.1016/j.tibtech.2022.01.007

Engineering tissue morphogenesis: taking it up a Notch

Laura A. Tiemeijer, Sami Sanlidag, Carlijn V.C. Bouten, Cecilia Sahlgren^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article or Literature Review › peer-review

10 Citations (Scopus)

51 Downloads (Pure)

Abstract

Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

Original language	English
Pages (from-to)	945-957
Number of pages	13
Journal	Trends in Biotechnology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.tibtech.2022.01.007
Publication status	Published - Aug 2022
MoE publication type	A2 Review article in a scientific journal

Keywords

Notch signaling
Notch signaling modulation
tissue patterning
morphogenesis
ligand immobilization

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10.1016/j.tibtech.2022.01.007Licence: CC BY

2022 Engineering tissue morphogenesis; taking it up a Notch (Tiemeijer and Sanlidag et al.) Trends Biotechnol_Version of recordFinal published version, 1.93 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe2022040126604

SignalSheets: Multilayer mechanosignalling in vascular homeostasis
Sahlgren, C. (Principal Investigator)
01/09/20 → 31/08/24
Project: Research Council of Finland/Other Research Councils
BACE: Center of Excellence in Bioelectronic Activation of Cell Functions
Österbacka, R. (Principal Investigator), Sjöqvist, M. (Co-Principal Investigator), Sahlgren, C. (Co-Principal Investigator), Torsi, L. (Co-Principal Investigator), Lindfelt, M. (Co-Principal Investigator), Hellsten, L. (Co-Investigator), Tewari, A. (Co-Investigator), Luukkonen, A. (Co-Investigator), Martinez Klimova, E. (Co-Investigator), Schmit, A. (Co-Investigator), Eklund, A. (Co-Investigator) & Gounani, Z. (Co-Investigator)
01/03/19 → 31/12/23
Project: Foundation
CellMech: Center of Excellence in Cellular Mechanostasis
Sahlgren, C. (Principal Investigator), Sistonen, L. (Principal Investigator), Eriksson, J. (Principal Investigator), Toivola, D. (Principal Investigator), Meinander, A. (Principal Investigator), Cheng, F. (Principal Investigator) & Jacquemet, G. (Principal Investigator)
01/03/19 → 29/02/24
Project: Foundation

Cite this

@article{18434f66096944428e9ef1e36b85baaf,

title = "Engineering tissue morphogenesis: taking it up a Notch",

abstract = "Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.",

keywords = "Notch signaling, Notch signaling modulation, tissue patterning, morphogenesis, ligand immobilization",

author = "Tiemeijer, {Laura A.} and Sami Sanlidag and Bouten, {Carlijn V.C.} and Cecilia Sahlgren",

year = "2022",

month = aug,

doi = "10.1016/j.tibtech.2022.01.007",

language = "English",

volume = "40",

pages = "945--957",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - Engineering tissue morphogenesis: taking it up a Notch

AU - Tiemeijer, Laura A.

AU - Sanlidag, Sami

AU - Bouten, Carlijn V.C.

AU - Sahlgren, Cecilia

PY - 2022/8

Y1 - 2022/8

N2 - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

AB - Recreating functional tissues through bioengineering strategies requires steering of complex cell fate decisions. Notch, a juxtacrine signaling pathway, regulates cell fate and controls cellular organization with local precision. The engineering-friendly characteristics of the Notch pathway provide handles for engineering tissue patterning and morphogenesis. We discuss the physiological significance and mechanisms of Notch signaling with an emphasis on its potential use for engineering complex tissues. We highlight the current state of the art of Notch activation and provide a view on the design aspects, opportunities, and challenges in modulating Notch for tissue-engineering strategies. We propose that finely tuned control of Notch contributes to the generation of tissues with accurate form and functionality.

KW - Notch signaling

KW - Notch signaling modulation

KW - tissue patterning

KW - morphogenesis

KW - ligand immobilization

U2 - 10.1016/j.tibtech.2022.01.007

DO - 10.1016/j.tibtech.2022.01.007

M3 - Review Article or Literature Review

SN - 0167-7799

VL - 40

SP - 945

EP - 957

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 8

ER -

Engineering tissue morphogenesis: taking it up a Notch

Abstract

Keywords

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Projects

SignalSheets: Multilayer mechanosignalling in vascular homeostasis

BACE: Center of Excellence in Bioelectronic Activation of Cell Functions

CellMech: Center of Excellence in Cellular Mechanostasis

Cite this