Engineered Extracellular Vesicles for Cancer Therapy

Xu Zhang; Hongbo Zhang; Jianmei Gu; Jiayin Zhang; Hui Shi; Hui Qian; Dongqing Wang; Wenrong Xu; Jianming Pan; Hélder A. Santos

doi:10.1002/adma.202005709

Engineered Extracellular Vesicles for Cancer Therapy

Xu Zhang, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan, Hélder A. Santos^*

^*Corresponding author for this work

Research output: Contribution to journal › Review Article or Literature Review › peer-review

294 Citations (Scopus)

533 Downloads (Pure)

Abstract

Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell-to-cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo-loading and tumor-targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.

Original language	English
Article number	2005709
Journal	Advanced Materials
Volume	33
Issue number	14
DOIs	https://doi.org/10.1002/adma.202005709
Publication status	Published - 8 Apr 2021
MoE publication type	A2 Review article in a scientific journal

Access to Document

10.1002/adma.202005709

Zhang et al., 2021 AM parallel Accepted author manuscript, 11.5 MB

https://urn.fi/URN:NBN:fi-fe202201148374

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and Engineering
Facility/equipment: Facility

Cite this

@article{facf0846d8eb433d96e24c1d85653af5,

title = "Engineered Extracellular Vesicles for Cancer Therapy",

abstract = "Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell-to-cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo-loading and tumor-targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.",

author = "Xu Zhang and Hongbo Zhang and Jianmei Gu and Jiayin Zhang and Hui Shi and Hui Qian and Dongqing Wang and Wenrong Xu and Jianming Pan and Santos, {H{\'e}lder A.}",

year = "2021",

month = apr,

day = "8",

doi = "10.1002/adma.202005709",

language = "English",

volume = "33",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley",

number = "14",

}

TY - JOUR

T1 - Engineered Extracellular Vesicles for Cancer Therapy

AU - Zhang, Xu

AU - Zhang, Hongbo

AU - Gu, Jianmei

AU - Zhang, Jiayin

AU - Shi, Hui

AU - Qian, Hui

AU - Wang, Dongqing

AU - Xu, Wenrong

AU - Pan, Jianming

AU - Santos, Hélder A.

PY - 2021/4/8

Y1 - 2021/4/8

N2 - Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell-to-cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo-loading and tumor-targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.

AB - Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell-to-cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo-loading and tumor-targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.

U2 - 10.1002/adma.202005709

DO - 10.1002/adma.202005709

M3 - Review Article or Literature Review

SN - 0935-9648

VL - 33

JO - Advanced Materials

JF - Advanced Materials

IS - 14

M1 - 2005709

ER -

Engineered Extracellular Vesicles for Cancer Therapy

Abstract

Access to Document

Fingerprint

Equipment

Åbo Akademi Functional Printing Center

Cite this