Engineered Extracellular Vesicles for Cancer Therapy

Xu Zhang, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan, Hélder A. Santos*

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

206 Citations (Scopus)
156 Downloads (Pure)


Extracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer. As a result of their natural properties to mediate cell-to-cell communication and their high physiochemical stability and biocompatibility, EVs are considered as excellent delivery vehicles for a variety of therapeutic agents such as nucleic acids and proteins, drugs, and nanomaterials. Increasing studies have shown that EVs can be modified, engineered, or designed to improve their efficiency, specificity, and safety for cancer therapy. Herein, a comprehensive overview of the recent advances in the strategies and methodologies of engineering EVs for scalable production and improved cargo-loading and tumor-targeting is provided. Additionally, the potential applications of engineered EVs in cancer therapy are discussed by presenting prominent examples, and the opportunities and challenges for translating engineered EVs into clinical practice are evaluated.

Original languageEnglish
Article number2005709
JournalAdvanced Materials
Issue number14
Publication statusPublished - 8 Apr 2021
MoE publication typeA2 Review article in a scientific journal


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