Endocytic Trafficking of Integrins in Cell Migration

Paul, Guillaume Jacquemet, Caswell

Research output: Contribution to journalReview Article or Literature ReviewScientificpeer-review

129 Citations (Scopus)

Abstract

Integrins are a family of heterodimeric receptors that bind to components of the extracellular matrix and influence cellular processes as varied as proliferation and migration. These effects are achieved by tight spatiotemporal control over intracellular signalling pathways, including those that mediate cytoskeletal reorganisation. The ability of integrins to bind to ligands is governed by integrin conformation, or activity, and this is widely acknowledged to be an important route to the regulation of integrin function. Over the last 15 years, however, the pathways that regulate endocytosis and recycling of integrins have emerged as major players in controlling integrin action, and studying integrin trafficking has revealed fresh insight into the function of this fascinating class of extracellular matrix receptors, in particular in the context of cell migration and invasion. Here, we review our current understanding of the contribution of integrin trafficking to cell motility.
Original languageUndefined/Unknown
Pages (from-to)R1092–R1105
JournalCurrent Biology
Volume25
Issue number22
DOIs
Publication statusPublished - 2015
MoE publication typeA2 Review article in a scientific journal

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