Electronic biosensors based on EGOFETs

Mohammad Y. Mulla, Luisa Torsi, Kyriaki Manoli

Research output: Chapter in Book/Conference proceedingChapterScientificpeer-review

1 Citation (Scopus)

Abstract

There is an increasing interest for low cost, ultrasensitive, time saving yet reliable, point-of-care bioelectronic sensors. Electrolyte gated organic field effect transistors (EGOFETs) are proven compelling transducers for various sensing applications, offering direct electronic, label-free transduction of bio-recognition events along with miniaturization, fast data handling and processing. Given that field effect transistors act as intrinsically signal amplifiers, even a small change of a chemical or biological quantity may significantly alter the output electronic signal. In EGOFETs selectivity can be guaranteed by the immobilization of bioreceptors able to bind specifically a target analyte. The layer of receptors can be linked to one of the electronic active interfaces of the transistor, and the interactions with a target molecule affect the electronic properties of the device. The present chapter discusses main aspects of EGOFETs transducers along with detailed examples of how to tailor the device interfaces with desired functionality. The development of an “electronic tongue” based on an EGOFET device coupled to odorant binding proteins (OBPs) for enantiomers differentiation is presented.
Original languageEnglish
Title of host publicationOdorant Binding and Chemosensory Proteins
EditorsPaolo Pelosi, Wolfgang Knoll
PublisherElsevier
Chapter17
Pages403-433
Number of pages31
Volume642
ISBN (Print)978-0-12-821157-1
DOIs
Publication statusPublished - 2020
MoE publication typeA3 Part of a book or another research book

Publication series

NameMethods in Enzymology
PublisherElsevier
ISSN (Print)0076-6879

Keywords

  • Organic bioelectronics
  • Electrolyte-gated organic field effect transistors
  • Odorant binding proteins
  • Electronic sensing
  • Biosensors
  • Biofunctional layer
  • Enantiomeric differentiation
  • Biological olfactory systems
  • Self assembled monolayer

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