Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing

Angelo Tricase; Anna Imbriano; Eleonora Macchia; Rosaria Anna Picca; Davide Blasi; Luisa Torsi; Paolo Bollella

doi:10.1109/FLEPS53764.2022.9781585

Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing

Angelo Tricase^*
, Anna Imbriano
, Eleonora Macchia
, Rosaria Anna Picca
, Davide Blasi
, Luisa Torsi
, Paolo Bollella

^*Corresponding author for this work

Physics

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

3 Citations (Scopus)

Abstract

In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.

Original language	English
Title of host publication	2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)
Publisher	the Institute of Electrical and Electronics Engineers, Inc.
ISBN (Electronic)	9781665442732
ISBN (Print)	9781665483605
DOIs	https://doi.org/10.1109/FLEPS53764.2022.9781585
Publication status	Published - 2022
MoE publication type	A4 Article in a conference publication
Event	2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022 - Vienna, Austria Duration: 10 Jul 2022 → 13 Jul 2022

Conference

Conference	2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022
Country/Territory	Austria
City	Vienna
Period	10/07/22 → 13/07/22

Funding

V. ACKNOWLEDGMENT The following funding agencies are acknowledged: Academy of Finland projects #316881, #316883 ‘‘Spatiotemporal control of Cell Functions’’, #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagno-sis”; Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020; Dottorati innovativi con caratterizzazione industriale—PON R&I 2014–2020; “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica” (BioElSens&Fuel); SiMBiT—Single molecule bio-electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB—Sviluppo di piat-taforme meccatroniche, genomiche e bioinformatiche per l’oncologia di precisio-ne—ARS01_01195-PON “RICERCA E INNOVAZIONE” 2014–2020; Åbo Akademi Uni-versity CoE “Bioelectronic activation of cell functions”; and CSGI are acknowledged for partial financial support.

Keywords

anti-IgG
cyclic voltammetry
hydrogen bonding
modified electrodes
self assembled monolayers

Access to Document

10.1109/FLEPS53764.2022.9781585Licence: All rights reserved

Cite this

Tricase, A., Imbriano, A., Macchia, E., Picca, R. A., Blasi, D., Torsi, L., & Bollella, P. (2022). Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing. In 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS) the Institute of Electrical and Electronics Engineers, Inc.. https://doi.org/10.1109/FLEPS53764.2022.9781585

@inproceedings{378a2d727e754f29bce1030c60a27c2b,

title = "Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing",

abstract = "In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.",

keywords = "anti-IgG, cyclic voltammetry, hydrogen bonding, modified electrodes, self assembled monolayers",

author = "Angelo Tricase and Anna Imbriano and Eleonora Macchia and Picca, \{Rosaria Anna\} and Davide Blasi and Luisa Torsi and Paolo Bollella",

note = "BOF 15/1 EK Funding Information: V. ACKNOWLEDGMENT The following funding agencies are acknowledged: Academy of Finland projects \#316881, \#316883 {\textquoteleft}{\textquoteleft}Spatiotemporal control of Cell Functions{\textquoteright}{\textquoteright}, \#332106 {\textquotedblleft}ProSiT{\textemdash}Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagno-sis{\textquotedblright}; Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell{\textquoteright}HIV (6CDD3786); Research for Innovation REFIN{\textemdash}Regione Puglia POR PUGLIA FESR-FSE 2014/2020; Dottorati innovativi con caratterizzazione industriale{\textemdash}PON R\&I 2014{\textendash}2020; {\textquotedblleft}Sensore bio-elettronico usa-e-getta per l{\textquoteright}HIV autoalimentato da una cella a combustibile biologica{\textquotedblright} (BioElSens\&Fuel); SiMBiT{\textemdash}Single molecule bio-electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB{\textemdash}Sviluppo di piat-taforme meccatroniche, genomiche e bioinformatiche per l{\textquoteright}oncologia di precisio-ne{\textemdash}ARS01\_01195-PON {\textquotedblleft}RICERCA E INNOVAZIONE{\textquotedblright} 2014{\textendash}2020; {\AA}bo Akademi Uni-versity CoE {\textquotedblleft}Bioelectronic activation of cell functions{\textquotedblright}; and CSGI are acknowledged for partial financial support. Publisher Copyright: {\textcopyright} 2022 IEEE.; 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022 ; Conference date: 10-07-2022 Through 13-07-2022",

year = "2022",

doi = "10.1109/FLEPS53764.2022.9781585",

language = "English",

isbn = "9781665483605",

booktitle = "2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)",

publisher = "the Institute of Electrical and Electronics Engineers, Inc.",

}

Tricase, A, Imbriano, A, Macchia, E, Picca, RA, Blasi, D, Torsi, L & Bollella, P 2022, Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing. in 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). the Institute of Electrical and Electronics Engineers, Inc., 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022, Vienna, Austria, 10/07/22. https://doi.org/10.1109/FLEPS53764.2022.9781585

Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing. / Tricase, Angelo; Imbriano, Anna; Macchia, Eleonora et al.
2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS). the Institute of Electrical and Electronics Engineers, Inc., 2022.

Research output: Chapter in Book/Conference proceeding › Published conference proceeding › Scientific › peer-review

TY - GEN

T1 - Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing

AU - Tricase, Angelo

AU - Imbriano, Anna

AU - Macchia, Eleonora

AU - Picca, Rosaria Anna

AU - Blasi, Davide

AU - Torsi, Luisa

AU - Bollella, Paolo

N1 - BOF 15/1 EK Funding Information: V. ACKNOWLEDGMENT The following funding agencies are acknowledged: Academy of Finland projects #316881, #316883 ‘‘Spatiotemporal control of Cell Functions’’, #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagno-sis”; Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020; Dottorati innovativi con caratterizzazione industriale—PON R&I 2014–2020; “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica” (BioElSens&Fuel); SiMBiT—Single molecule bio-electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB—Sviluppo di piat-taforme meccatroniche, genomiche e bioinformatiche per l’oncologia di precisio-ne—ARS01_01195-PON “RICERCA E INNOVAZIONE” 2014–2020; Åbo Akademi Uni-versity CoE “Bioelectronic activation of cell functions”; and CSGI are acknowledged for partial financial support. Publisher Copyright: © 2022 IEEE.

PY - 2022

Y1 - 2022

N2 - In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.

AB - In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.

KW - anti-IgG

KW - cyclic voltammetry

KW - hydrogen bonding

KW - modified electrodes

KW - self assembled monolayers

UR - https://www.scopus.com/pages/publications/85137170796

U2 - 10.1109/FLEPS53764.2022.9781585

DO - 10.1109/FLEPS53764.2022.9781585

M3 - Published conference proceeding

AN - SCOPUS:85137170796

SN - 9781665483605

BT - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)

PB - the Institute of Electrical and Electronics Engineers, Inc.

T2 - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022

Y2 - 10 July 2022 through 13 July 2022

ER -

Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing

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Keywords

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