TY - GEN
T1 - Electrochemical Investigation of Self-Assembling Monolayers toward Ultrasensitive Sensing
AU - Tricase, Angelo
AU - Imbriano, Anna
AU - Macchia, Eleonora
AU - Picca, Rosaria Anna
AU - Blasi, Davide
AU - Torsi, Luisa
AU - Bollella, Paolo
N1 - BOF 15/1 EK
Funding Information:
V. ACKNOWLEDGMENT The following funding agencies are acknowledged: Academy of Finland projects #316881, #316883 ‘‘Spatiotemporal control of Cell Functions’’, #332106 “ProSiT—Protein Detection at the Single-Molecule Limit with a Self-powered Organic Transistor for HIV early diagno-sis”; Biosensori analitici usa-e getta a base di transistori organici auto-alimentati per la rivelazione di biomarcatori proteomici alla singola molecola per la diagnostica decentrata dell’HIV (6CDD3786); Research for Innovation REFIN—Regione Puglia POR PUGLIA FESR-FSE 2014/2020; Dottorati innovativi con caratterizzazione industriale—PON R&I 2014–2020; “Sensore bio-elettronico usa-e-getta per l’HIV autoalimentato da una cella a combustibile biologica” (BioElSens&Fuel); SiMBiT—Single molecule bio-electronic smart system array for clinical testing (Grant agreement ID: 824946); PMGB—Sviluppo di piat-taforme meccatroniche, genomiche e bioinformatiche per l’oncologia di precisio-ne—ARS01_01195-PON “RICERCA E INNOVAZIONE” 2014–2020; Åbo Akademi Uni-versity CoE “Bioelectronic activation of cell functions”; and CSGI are acknowledged for partial financial support.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.
AB - In this paper we report a combined theoretical and experimental approach for analyzing Self Assembled Monolayers (SAMs) modified electrodes. Three different SAMs were compared, consisting in a mixed SAMs of amides and carboxylic groups (Deactivated SAMs), a SAM functionalized with an antibody (Anti-IgG SAMs), and SAM functionalized with two different proteins, Anti-IgG and Bovine Serum Albumin (BSA). Each of these samples is used to describe a different component of a SAMs modified gold electrode implemented in an Electrolyte Gated - Organic Field Effect Transistor Biosensor, where the presence of a diffuse hydrogen bonding between SAMs chains plays a key role for reaching the performance of this device, able to reach the single molecule limit of detection.
KW - anti-IgG
KW - cyclic voltammetry
KW - hydrogen bonding
KW - modified electrodes
KW - self assembled monolayers
UR - http://www.scopus.com/inward/record.url?scp=85137170796&partnerID=8YFLogxK
U2 - 10.1109/FLEPS53764.2022.9781585
DO - 10.1109/FLEPS53764.2022.9781585
M3 - Conference contribution
AN - SCOPUS:85137170796
SN - 9781665483605
BT - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS)
PB - the Institute of Electrical and Electronics Engineers, Inc.
T2 - 2022 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2022
Y2 - 10 July 2022 through 13 July 2022
ER -