Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen, M Silvennoinen, P Vainio, Lea Sistonen, LG Koch, SL Britton, H Kainulainen

Research output: Contribution to journalArticleScientificpeer-review

26 Citations (Scopus)


Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)46–54
Number of pages9
JournalExperimental Gerontology
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed


  • aging
  • oxidative stress
  • physical activity
  • sirtuin
  • skeletal muscle

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