Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen; M Silvennoinen; P Vainio; Lea Sistonen; LG Koch; SL Britton; H Kainulainen

doi:10.1016/j.exger.2016.03.015

Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

S Karvinen, M Silvennoinen, P Vainio, Lea Sistonen, LG Koch, SL Britton, H Kainulainen

Research output: Contribution to journal › Article › Scientific › peer-review

30 Citations (Scopus)

Abstract

Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	46–54
Number of pages	9
Journal	Experimental Gerontology
Volume	79
DOIs	https://doi.org/10.1016/j.exger.2016.03.015
Publication status	Published - 2016
MoE publication type	A1 Journal article-refereed

Keywords

aging
oxidative stress
physical activity
sirtuin
skeletal muscle

Access to Document

10.1016/j.exger.2016.03.015

Cite this

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title = "Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins",

abstract = "Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.",

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T1 - Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins

AU - Karvinen, S

AU - Silvennoinen, M

AU - Vainio, P

AU - Sistonen, Lea

AU - Koch, LG

AU - Britton, SL

AU - Kainulainen, H

PY - 2016

Y1 - 2016

N2 - Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

AB - Conclusion: Our finding of elevated SIRT3 levels in HCR rats is in line with previous studies; SIRT3 in general is linked to elevated fatty acid oxidation and oxidative phosphorylation, which previously have been associated with metabolic profile of HCRs. HSF1, HSF2 and Hsp27 levels increased with aging, showing that aged muscles responded to aging-related stress. Our study shows for the first time that SIRT3 protein level is linked to high inborn aerobic capacity, and may be directly interconnected to longevity. (C) 2016 Elsevier Inc. All rights reserved.

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

KW - aging

KW - oxidative stress

KW - physical activity

KW - sirtuin

KW - skeletal muscle

U2 - 10.1016/j.exger.2016.03.015

DO - 10.1016/j.exger.2016.03.015

M3 - Artikel

SN - 0531-5565

VL - 79

SP - 46

EP - 54

JO - Experimental Gerontology

JF - Experimental Gerontology

ER -