Abstract
Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic cell division simulator, to investigate the growth kinetics and interface roughness dynamics of epithelial tissue growth on heterogeneous substrates with varying topologies. The results show that the presence of quenched disorder has a clear effect on the colony morphology and the roughness scaling of the interface in the moving interface regime. In a medium with quenched disorder, the tissue interface has a smaller interface roughness exponent, α, and a larger growth exponent, β. The scaling exponents also depend on the topology of the substrate and cannot be categorized by well-known universality classes.
| Translated title of the contribution | Inverkan av substratojämnheter och topologi på epitelvävnaders tillväxtdynamik |
|---|---|
| Original language | English |
| Article number | 054405 |
| Journal | Physical Review E |
| Volume | 108 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 13 Nov 2023 |
| MoE publication type | A1 Journal article-refereed |
Funding
M.K. thanks the Discovery and Canada Research Chairs Programs of the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support. M.M. thanks Western University's Science International Engagement Fund (SIEF) for travel support. Computational resources were provided by the Finnish Grid and Cloud Infrastructure FGCI, funded by the Academy of Finland, Grant No. 304973.