There has been notably little convergence between information organization and information use studies. A framework for explicating the contextual interplay of information interactions and infrastructures of information, and more specifically the interface of information work and knowledge organization systems, is proposed. The theoretical foundations of the framework are based on systems theory and ecological approach. It is suggested that the interplay of information use and information infrastructures may be conceptualized as a systemic interaction, which is driven by the simultaneous influence of human activity related warrants and infrastructural affordances and constraints. The model provides an instrument that explicates the interplay of human information use and information infrastructures.