Dynamics and Control of Intensified Extractive Distillation with Preconcentration: A Case Study of Separating N-Propanol/Water with Minimum-Boiling Azeotrope

•A case study of intensified extractive dsitillation (ED) with preconcentration investigating the separation of N-propanol/Water using N-methyl-2-pyrrolidone as a heavy entrainer is developed. •We reformed the conventional preconcentration distillation column(PDC) to a stripping column. •The modified three-column configurations achieved 14.4% reduction in total annual cost (TAC) and 17.9% reduction in CO₂ emissions as compared to the basic design. •To maintain the desired product purity, robust plantwide control structures based on proportional-integral feedback controllers were developed to tackle ±20% throughout and feed composition disturbances.