Durable nanofibrous matrices augmented with hydrotalcite-like compounds for cutaneous regeneration of burn wounds

Mohan Vimala Devi, S.S. Liji Sobhana, Punalur John Shiny, Giriprasath Ramanathan, Sekar Jeyakumar Grace Felciya, Velswamy Poornima, Sathiah Thennarasu, Pedro Fardim, Uma Tiruchirapalli Sivagnanam*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)

Abstract

Electrospinning of Gelatin (G) and Poly-3-hydroxybutyric acid (P) incorporated with anionic drug (AgSD) loaded hydrotalcite (L) (L-AgSD) is carried out to fabricate a nanofibrous scaffold which would recreate the native extracellular matrix suitable for cutaneous regeneration. The L-AgSD complex was augmented into electrospun nanofibers of diameter 100–140 nm. The physiochemical (XRD, FTIR), morphological (SEM), mechanical (tensile strength) and biological (in vitro and in vivo) properties of the developed wound construct were studied. Antimicrobial studies reveal the potential activity against microbial infection. Studies on drug release kinetics demonstrate a controlled release of 86% in 72 h. In vitro biocompatibility studies using NIH 3T3 fibroblast cell line showed excellent cell adhesion and cell proliferation indicating the biocompatible nature of the scaffold. The matrix accelerated wound healing on Pseudomonas infected burn wound induced on rat models. The tailored matrix is promising as an impending nanohybrid construct for burn wound injuries with controlled drug release and antibacterial activity.
Original languageEnglish
Article number105476
JournalApplied Clay Science
Volume187
DOIs
Publication statusPublished - 1 Feb 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • Biocompatibility
  • Burns
  • In vivo study
  • LDH
  • Nanofibrous matrix
  • Wound healing

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