DNA origami design and implementation: the Romanian map

Laura Ioana Popa, Ana-Maria Dobre, Corina Itcus*, Alexandru Amarioarei, Andrei Paun, Mihaela Paun, Felicia Pop, Iris Tusa, Minh-Kha Nguyen, Anton Kuzyk, Eugen Czeizler

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

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Abstract

Since its introduction in the early 2000s, DNA origami had a big impact on the development of nanotechnology by gathering numerous applications. During this time, many tools were designed and used to generate arbitrary shapes capable of self-assembly which make this technique more approachable. In this paper, we have created the map of Romania at nanoscale dimensions by using a new open-source software–PERDIX. For this purpose, we used a scaffold strand with a length of 6959 nucleotides and 162 staple strands with a variable length ranging between 20 and 63 nucleotides. All the computational tools that were used in this experiment are open-source and user-friendly.
Original languageEnglish
Pages (from-to)1816
Number of pages1822
JournalRomanian Biotechnological Letters
Volume25
Issue number4
Publication statusPublished - 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • Nanotechnology
  • DNA origami
  • Nanostructure
  • Romanian map

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