Dissolution patterns of biocompatible glasses in 2-amino-2-hydroxymethyl-propane-1,3-diol (Tris) buffer

Susanne Fagerlund, Leena Hupa, Mikko Hupa

    Research output: Contribution to journalArticleScientificpeer-review

    50 Citations (Scopus)


    A continuous flow measurement system with sensitive on-line ion analysis has been applied to study the initial dissolution behaviour of biocompatible glasses in Tris. Altogether 16 glasses with widely varying compositions were studied. The measurement system allowed for quantitative determination of the time-dependent rates of dissolution of sodium, potassium, calcium, magnesium, silicon and phosphorus during the first 10-15 min in contact with Tris solution. The dissolution rates of the different ions showed significant glass to glass variations, but all glasses studied showed one of four distinct dissolution patterns. The ion dissolution rates after an exposure of 1000 s, expressed as the normalized surface-specific mass loss rates, were compared with the in vitro and in vivo reactivity of the glasses as predicted by models in the literature. The results showed a clear correlation between the dissolution rates of the glasses in Tris and their reactivity as measured by other different methods. Consequently, the measured short-term dissolution patterns could be used to determine which glasses are suitable as bioactive, biodegradable, or inert biomaterials for medical devices.
    Original languageUndefined/Unknown
    Pages (from-to)5400–5410
    Number of pages11
    JournalActa Biomaterialia
    Issue number2
    Publication statusPublished - 2013
    MoE publication typeA1 Journal article-refereed


    • Biocompatible glass
    • Dissolution profile
    • Inductively coupled plasma
    • Ion release
    • Tris buffer

    Cite this