Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

Laura Aalto-Setälä, Peter Uppstu, Polina Sinitsyna, Nina C. Lindfors, Leena Hupa*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications in granule form. However, utilization of the glass in scaffold form has been limited by the high tendency of the glass to crystallize during sintering. Here, careful optimization of sintering parameters enabled the manufacture of porous amorphous S53P4 scaffolds with a strength high enough for surgical procedures in bone applications (5 MPa). Sintering was conducted in a laboratory furnace for times ranging from 25 to 300 min at 630 °C, i.e., narrowly below the commencement of the crystallization. The phase composition of the scaffolds was verified with XRD, and the ion release was tested in vitro and compared with granules in continuous flow of Tris buffer and simulated body fluid (SBF). The amorphous, porous S53P4 scaffolds present the possibility of using the glass composition in a wider range of applications.
Original languageEnglish
JournalMaterials
Volume14
Issue number17
DOIs
Publication statusPublished - 26 Aug 2021
MoE publication typeA1 Journal article-refereed

Keywords

  • bioactive glasses
  • S53P4
  • glass scaffolds
  • sintering
  • in vitro dissolution
  • dynamic dissolution
  • biomaterials
  • Tissue engineering

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