Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth

Costantino Luca; Stefania Ferrari; Matteo Santucci; Outi Salo-Ahen; Emanuele Carosati; Silvia Franchini; Lauriola Angela; Cecilia Pozzi; Gaetano Marverti; Matteo Trande; Gozzi Gaia; Puneet Saxena; Giuseppe Cannazza; Lorena Losi; Daniela Cardinale; Alberto Venturelli; Antonio Quotadamo; Pasquale Linciano; Remo Guerrini; Salvatore Pacificio; Rosaria Luciani; Filippo Genovese; Henrich Stefan; Alboni Silvia; Nuno Santarem; Anabela Cordeiro-da-Silva; Elisa Giovannetti; Godefridus Peters; Paolo Pinton; Alessandro Rimessi; Gabriele Cruciani; Robert Stroud; Rebecca Wade; Stefano Mangani; Domenico D'Arca; Glauco Ponterini; Maria Costi

doi:10.26434/chemrxiv.14156918.v1

Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth

Costantino Luca, Stefania Ferrari, Matteo Santucci, Outi Salo-Ahen, Emanuele Carosati, Silvia Franchini, Lauriola Angela, Cecilia Pozzi, Gaetano Marverti, Matteo Trande, Gozzi Gaia, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Remo Guerrini, Salvatore PacificioRosaria Luciani, Filippo Genovese, Henrich Stefan, Alboni Silvia, Nuno Santarem, Anabela Cordeiro-da-Silva, Elisa Giovannetti, Godefridus Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert Stroud, Rebecca Wade, Stefano Mangani, Domenico D'Arca, Glauco Ponterini, Maria Costi

Pharmacy

Research output: Contribution to journal › Article › Scientific

Original language	English
Journal	ChemRxiv
DOIs	https://doi.org/10.26434/chemrxiv.14156918.v1
Publication status	Submitted - 2021
MoE publication type	B1 Article in a scientific magazine

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10.26434/chemrxiv.14156918.v1Licence: CC BY-NC-ND

Cite this

Luca, C., Ferrari, S., Santucci, M., Salo-Ahen, O., Carosati, E., Franchini, S., Angela, L., Pozzi, C., Marverti, G., Trande, M., Gaia, G., Saxena, P., Cannazza, G., Losi, L., Cardinale, D., Venturelli, A., Quotadamo, A., Linciano, P., Guerrini, R., ... Costi, M. (2021). Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth. Manuscript submitted for publication. https://doi.org/10.26434/chemrxiv.14156918.v1

@article{d0880b68e21e4bd9a45fb4c8d25cd917,

title = "Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth",

author = "Costantino Luca and Stefania Ferrari and Matteo Santucci and Outi Salo-Ahen and Emanuele Carosati and Silvia Franchini and Lauriola Angela and Cecilia Pozzi and Gaetano Marverti and Matteo Trande and Gozzi Gaia and Puneet Saxena and Giuseppe Cannazza and Lorena Losi and Daniela Cardinale and Alberto Venturelli and Antonio Quotadamo and Pasquale Linciano and Remo Guerrini and Salvatore Pacificio and Rosaria Luciani and Filippo Genovese and Henrich Stefan and Alboni Silvia and Nuno Santarem and Anabela Cordeiro-da-Silva and Elisa Giovannetti and Godefridus Peters and Paolo Pinton and Alessandro Rimessi and Gabriele Cruciani and Robert Stroud and Rebecca Wade and Stefano Mangani and Domenico D'Arca and Glauco Ponterini and Maria Costi",

year = "2021",

doi = "10.26434/chemrxiv.14156918.v1",

language = "English",

journal = "ChemRxiv",

issn = "2573-2293",

}

Luca, C, Ferrari, S, Santucci, M, Salo-Ahen, O, Carosati, E, Franchini, S, Angela, L, Pozzi, C, Marverti, G, Trande, M, Gaia, G, Saxena, P, Cannazza, G, Losi, L, Cardinale, D, Venturelli, A, Quotadamo, A, Linciano, P, Guerrini, R, Pacificio, S, Luciani, R, Genovese, F, Stefan, H, Silvia, A, Santarem, N, Cordeiro-da-Silva, A, Giovannetti, E, Peters, G, Pinton, P, Rimessi, A, Cruciani, G, Stroud, R, Wade, R, Mangani, S, D'Arca, D, Ponterini, G & Costi, M 2021, 'Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth', ChemRxiv. https://doi.org/10.26434/chemrxiv.14156918.v1

TY - JOUR

T1 - Disrupters of the Thymidylate Synthase Homodimer Accelerate Its Proteasomal Degradation and Inhibit Cancer Growth

AU - Luca, Costantino

AU - Ferrari, Stefania

AU - Santucci, Matteo

AU - Salo-Ahen, Outi

AU - Carosati, Emanuele

AU - Franchini, Silvia

AU - Angela, Lauriola

AU - Pozzi, Cecilia

AU - Marverti, Gaetano

AU - Trande, Matteo

AU - Gaia, Gozzi

AU - Saxena, Puneet

AU - Cannazza, Giuseppe

AU - Losi, Lorena

AU - Cardinale, Daniela

AU - Venturelli, Alberto

AU - Quotadamo, Antonio

AU - Linciano, Pasquale

AU - Guerrini, Remo

AU - Pacificio, Salvatore

AU - Luciani, Rosaria

AU - Genovese, Filippo

AU - Stefan, Henrich

AU - Silvia, Alboni

AU - Santarem, Nuno

AU - Cordeiro-da-Silva, Anabela

AU - Giovannetti, Elisa

AU - Peters, Godefridus

AU - Pinton, Paolo

AU - Rimessi, Alessandro

AU - Cruciani, Gabriele

AU - Stroud, Robert

AU - Wade, Rebecca

AU - Mangani, Stefano

AU - D'Arca, Domenico

AU - Ponterini, Glauco

AU - Costi, Maria

PY - 2021

Y1 - 2021

U2 - 10.26434/chemrxiv.14156918.v1

DO - 10.26434/chemrxiv.14156918.v1

M3 - Article

SN - 2573-2293

JO - ChemRxiv

JF - ChemRxiv

ER -