Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

D Mavrynsky; M Paivio; K Lundell; R Sillanpaa; LT Kanerva; Reko Leino

doi:10.1002/ejoc.200801248

Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

D Mavrynsky, M Paivio, K Lundell, R Sillanpaa, LT Kanerva, Reko Leino

Research output: Contribution to journal › Article › Scientific › peer-review

32 Citations (Scopus)

Abstract

Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis, This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

Original language	Undefined/Unknown
Pages (from-to)	1317–1320
Number of pages	4
Journal	European Journal of Organic Chemistry
Volume	2009
Issue number	9
DOIs	https://doi.org/10.1002/ejoc.200801248
Publication status	Published - 2009
MoE publication type	A1 Journal article-refereed

Keywords

Cyclopentadienyl ligands
Dynamic kinetic resolution
Enzyme catalysis
Racemization
Ruthenium

Access to Document

10.1002/ejoc.200801248

Cite this

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title = "Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols",

abstract = "Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis, This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)",

keywords = "Cyclopentadienyl ligands, Dynamic kinetic resolution, Enzyme catalysis, Racemization, Ruthenium, Cyclopentadienyl ligands, Dynamic kinetic resolution, Enzyme catalysis, Racemization, Ruthenium, Cyclopentadienyl ligands, Dynamic kinetic resolution, Enzyme catalysis, Racemization, Ruthenium",

author = "D Mavrynsky and M Paivio and K Lundell and R Sillanpaa and LT Kanerva and Reko Leino",

year = "2009",

doi = "10.1002/ejoc.200801248",

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journal = "European Journal of Organic Chemistry",

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T1 - Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium as Racemization Catalyst in the Dynamic Kinetic Resolution of Secondary Alcohols

AU - Mavrynsky, D

AU - Paivio, M

AU - Lundell, K

AU - Sillanpaa, R

AU - Kanerva, LT

AU - Leino, Reko

PY - 2009

Y1 - 2009

N2 - Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis, This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

AB - Dicarbonylchloro(pentabenzylcyclopentadienyl)ruthenium has been prepared and its structure confirmed by X-ray analysis, This complex shows excellent catalytic activity and modest stability against air in racemization reactions of secondary alcohols. In Candida antarctica lipase B (CAL-B) catalyzed dynamic kinetic resolution (DKR) of 1-phenyl- and 1-(furan-2-yl)ethanol compounds, the new complex shows improved performance as an alcohol racemization catalyst in comparison with its well-known pentaphenylcyclopentadienyl analogue, hitherto considered as the leading catalyst candidate. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

KW - Cyclopentadienyl ligands

KW - Dynamic kinetic resolution

KW - Enzyme catalysis

KW - Racemization

KW - Ruthenium

KW - Cyclopentadienyl ligands

KW - Dynamic kinetic resolution

KW - Enzyme catalysis

KW - Racemization

KW - Ruthenium

KW - Cyclopentadienyl ligands

KW - Dynamic kinetic resolution

KW - Enzyme catalysis

KW - Racemization

KW - Ruthenium

U2 - 10.1002/ejoc.200801248

DO - 10.1002/ejoc.200801248

M3 - Artikel

SN - 1434-193X

VL - 2009

SP - 1317

EP - 1320

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

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