TY - JOUR
T1 - Development of new probiotics by strain combinations
T2 - Is it possible to improve the adhesion to intestinal mucus?
AU - Collado, M. C.
AU - Meriluoto, J.
AU - Salminen, S.
N1 - Funding Information:
This work was supported by the Academy of Finland, Research Council for Biosciences and Environment (decision number 210309 to Åbo Akademi and 210310 to University of Turku). M. C. Collado is the recipient of a Postdoctoral Excellence grant from Conselleria Empresa , Universidad y Ciencia de la Generalitat, Valenciana, Spain (BPOSTDOC 06/016). Valio Ltd. (Helsinki, Finland) provided the probiotic mixture used in the study.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2007/6
Y1 - 2007/6
N2 - We evaluated the ability of commercial probiotic strains (Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve 99, and Propionibacterium freudenreichii ssp. shermanii JS) to adhere alone or in different combinations to immobilized mucus. Probiotic combinations were clearly able to enhance the adhesion of L. rhamnosus GG, L. rhamnosus LC705, and P. freudenreichii ssp. shermanii JS. For L. rhamnosus GG and P. freudenreichii JS, all the combinations significantly improved adhesion to intestinal mucus, from 29.7 to 34.9% and from 1.9 to 2.3%, respectively. The adhesion of L. rhamnosus LC 705 was improved from 0 to 46.4%. The adhesion of B. breve 99 was improved only in combination with L. rhamnosus GG and P. freudenreichii JS. Our results suggest that probiotic combinations could increase the beneficial health effects as compared with individual strains. Combinations of probiotic strains may therefore have synergistic adhesion effects, and such combinations also should be assessed in clinical studies.
AB - We evaluated the ability of commercial probiotic strains (Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve 99, and Propionibacterium freudenreichii ssp. shermanii JS) to adhere alone or in different combinations to immobilized mucus. Probiotic combinations were clearly able to enhance the adhesion of L. rhamnosus GG, L. rhamnosus LC705, and P. freudenreichii ssp. shermanii JS. For L. rhamnosus GG and P. freudenreichii JS, all the combinations significantly improved adhesion to intestinal mucus, from 29.7 to 34.9% and from 1.9 to 2.3%, respectively. The adhesion of L. rhamnosus LC 705 was improved from 0 to 46.4%. The adhesion of B. breve 99 was improved only in combination with L. rhamnosus GG and P. freudenreichii JS. Our results suggest that probiotic combinations could increase the beneficial health effects as compared with individual strains. Combinations of probiotic strains may therefore have synergistic adhesion effects, and such combinations also should be assessed in clinical studies.
KW - Adhesion
KW - Probiotic combinations
KW - Synergy
UR - http://www.scopus.com/inward/record.url?scp=34547654518&partnerID=8YFLogxK
U2 - 10.3168/jds.2006-456
DO - 10.3168/jds.2006-456
M3 - Article
C2 - 17517710
AN - SCOPUS:34547654518
SN - 0022-0302
VL - 90
SP - 2710
EP - 2716
JO - Journal of Dairy Science
JF - Journal of Dairy Science
IS - 6
ER -