Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

Denys Mavrynsky; Jani Rahkila; Daniel Bandarra; Soraia Martins; Margarida Meireles; Maria José Calhorda; Ida J. Kovács; István Zupkó; Mikko M. Hänninen; Reko Leino

doi:10.1021/om400234p

Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

Denys Mavrynsky, Jani Rahkila, Daniel Bandarra, Soraia Martins, Margarida Meireles, Maria José Calhorda, Ida J. Kovács, István Zupkó, Mikko M. Hänninen, Reko Leino

Research output: Contribution to journal › Article › Scientific › peer-review

5 Citations (Scopus)

Abstract

Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

Original language	Undefined/Unknown
Pages (from-to)	3012–3017
Number of pages	6
Journal	Organometallics
Volume	32
Issue number	10
DOIs	https://doi.org/10.1021/om400234p
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Access to Document

10.1021/om400234p

http://pubs.acs.org/doi/abs/10.1021/om400234p

Cite this

@article{5851a058e66a4c1eaaae510b5a0a1cfd,

title = "Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes",

abstract = "Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.",

author = "Denys Mavrynsky and Jani Rahkila and Daniel Bandarra and Soraia Martins and Margarida Meireles and \{Jos{\'e} Calhorda\}, Maria and Kov{\'a}cs, \{Ida J.\} and Istv{\'a}n Zupk{\'o} and H{\"a}nninen, \{Mikko M.\} and Reko Leino",

year = "2013",

doi = "10.1021/om400234p",

language = "Odefinierat/ok{\"a}nt",

volume = "32",

pages = "3012–3017",

journal = "Organometallics",

issn = "0276-7333",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Cytotoxicities of polysubstituted chlorodicarbonyl(cyclopentadienyl) and (indenyl)ruthenium complexes

AU - Mavrynsky, Denys

AU - Rahkila, Jani

AU - Bandarra, Daniel

AU - Martins, Soraia

AU - Meireles, Margarida

AU - José Calhorda, Maria

AU - Kovács, Ida J.

AU - Zupkó, István

AU - Hänninen, Mikko M.

AU - Leino, Reko

PY - 2013

Y1 - 2013

N2 - Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

AB - Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

U2 - 10.1021/om400234p

DO - 10.1021/om400234p

M3 - Artikel

SN - 0276-7333

VL - 32

SP - 3012

EP - 3017

JO - Organometallics

JF - Organometallics

IS - 10

ER -