Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity

John E. Eriksson

doi:10.1016/j.devcel.2025.05.015

Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity

John E. Eriksson^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › Scientific › peer-review

Abstract

In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.

Original language	English
Pages (from-to)	1655-1657
Number of pages	3
Journal	Developmental Cell
Volume	60
Issue number	12
DOIs	https://doi.org/10.1016/j.devcel.2025.05.015
Publication status	Published - 23 Jun 2025
MoE publication type	B1 Article in a scientific magazine

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10.1016/j.devcel.2025.05.015

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@article{6b97afddd51c488b94838a0ed2386020,

title = "Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity",

abstract = "In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.",

author = "Eriksson, \{John E.\}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = jun,

day = "23",

doi = "10.1016/j.devcel.2025.05.015",

language = "English",

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TY - JOUR

T1 - Cytoskeletal crosstalk in macrophages

T2 - Vimentin drives ECM remodeling in tumor invasion and tissue plasticity

AU - Eriksson, John E.

PY - 2025/6/23

Y1 - 2025/6/23

N2 - In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.

AB - In this issue of Developmental Cell, Huang et al. assess the role of vimentin intermediate filaments during extracellular matrix (ECM) degradation by macrophages. Vimentin stabilizes podosome clusters via CD11b in M2 macrophages, thereby reducing tumor collagen fiber and enhancing lung adenocarcinoma cancer invasion.

UR - https://www.scopus.com/pages/publications/105008234657

U2 - 10.1016/j.devcel.2025.05.015

DO - 10.1016/j.devcel.2025.05.015

M3 - Comment/debate

C2 - 40555172

AN - SCOPUS:105008234657

SN - 1534-5807

VL - 60

SP - 1655

EP - 1657

JO - Developmental Cell

JF - Developmental Cell

IS - 12

ER -

Cytoskeletal crosstalk in macrophages: Vimentin drives ECM remodeling in tumor invasion and tissue plasticity

Abstract

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