Creation of microrough surface on sintered bioactive glass microspheres

A Itala, EG Nordstrom, H Ylanen, HT Aro, Mikko Hupa

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    27 Citations (Scopus)

    Abstract

    Bioactive glasses are surface-active, generally silica-based, synthetic materials that form a firm chemical bond to bone. The aim of this study was to further enhance the bioactivity of glasses by creating a microroughness on their surface. Microroughness increases potential surface area for cell attachment and biomaterial-cell interactions. Three bioactive glasses of different composition were studied. Each material was flame-sprayed into microspheres, and a selected fraction of the spheres (250-300 mum) was sintered to form porous bioactive glass specimens. To create microrough surfaces, different acid etching techniques were tested. Atomic force microscopy (AFM) and back-scattered electron imaging of scanning electron microscopy (BEI-SEM) were used to characterize surface roughness. The degree of roughness was measured by AFM. A novel chemical-etching method, developed through intensive screening of different options, was found consistently to create the desired microroughness, with an average roughness value (R-a) of 0.35-0.52 mum and a root mean-square roughness value (R-rms) of 0.42-0.64 mum. Microroughening of the glass surface was obtained even in the internal parts of the porous glass matrices. Measured by BEI-SEM, the etching of a bioactive glass surface did not interfere with the formation of the characteristic surface reactions of bioactive glasses. This was confirmed by immersing the etched and control glass bodies in a simulated body fluid and tris(hydroxymethyl) aminomethane/HCl. The etching process did not significantly affect the mechanical strength of the sintered bioactive glass structures. Based on these experiments, it stems possible to create a reproducible microroughness of appropriate size on the surface of porous bioactive glass. The biologic benefits of such a surface treatment need to be validated with in vivo experiments. (C) 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 282-288, 2001.
    Original languageUndefined/Unknown
    Pages (from-to)282–288
    Number of pages7
    JournalJOURNAL OF BIOMEDICAL MATERIALS RESEARCH
    Volume56
    Issue number2
    Publication statusPublished - 2001
    MoE publication typeA1 Journal article-refereed

    Keywords

    • atomic force microscopy
    • microroughness
    • microspheres
    • scanning electron microscopy

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