Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application

Neeraj Prabhakar; Tuomas Näreoja; Eva von Haartman; Didem Sen Karaman; Hua Jiang; Sami Koho; Tatians A.Dolenko [Unknown]; Pekka E. Hänninen; Denis I. Vlasov; Victor G. Ralchenko; Satoru Hosomi; Igor I. Vlasov; Cecilia Sahlgren; Jessica M. Rosenholm

doi:10.1039/c3nr33926b

Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application

Neeraj Prabhakar
, Tuomas Näreoja
, Eva von Haartman
, Didem Sen Karaman
, Hua Jiang
, Sami Koho
, Tatians A.Dolenko [Unknown]
, Pekka E. Hänninen
, Denis I. Vlasov
, Victor G. Ralchenko
, Satoru Hosomi
, Igor I. Vlasov
, Cecilia Sahlgren
, Jessica M. Rosenholm

Research output: Contribution to journal › Article › Scientific › peer-review

106 Citations (Scopus)

Abstract

Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.

Original language	Undefined/Unknown
Pages (from-to)	3713–3722
Journal	Nanoscale
Volume	5
Issue number	9
DOIs	https://doi.org/10.1039/c3nr33926b
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Funding

All authors want to thank the Academy of Finland and Russian Foundation for Basic Research bilateral project “Fluorescent nanodiamond markers and nanodiamond–silica composites for biology and medicine: Efficiency and stability of photoemission versus surface chemistry” (AKA #137101, 10-03-91752-AF_a) for financial support. The authors further acknowledge funding from the Academy of Finland (projects #140193, #260599 (J.M.R.), #131034, #218062 (C.S.) #126998 (T.N. and P.H.)), Center of Excellence for Functional Materials (Finland) (D.S.K.), ISB graduate school (T.N. and P.H.), the Federal Program of the Ministry of Education and Science of Russia, grant 8398 (T.D.), Russian Ministry of Education and Science, President's grant for leading scientific schools no. 3076.2012.2 (I.V.), and from the Russian Academy of Sciences, program no. 24 (I.V.).

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10.1039/c3nr33926b

Targeting Notch signalign in cancer
Sahlgren, C. (Principal Investigator)
01/01/10 → 31/07/14
Project: Research

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Prabhakar, N., Näreoja, T., von Haartman, E., Sen Karaman, D., Jiang, H., Koho, S., [Unknown], T. A. D., Hänninen, P. E., Vlasov, D. I., Ralchenko, V. G., Hosomi, S., Vlasov, I. I., Sahlgren, C., & Rosenholm, J. M. (2013). Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application. Nanoscale, 5(9), 3713–3722. https://doi.org/10.1039/c3nr33926b

@article{5618fb4be9cc475b8cba156f80dbb560,

title = "Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application",

abstract = "Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.",

author = "Neeraj Prabhakar and Tuomas N{\"a}reoja and \{von Haartman\}, Eva and \{Sen Karaman\}, Didem and Hua Jiang and Sami Koho and [Unknown], \{Tatians A.Dolenko\} and H{\"a}nninen, \{Pekka E.\} and Vlasov, \{Denis I.\} and Ralchenko, \{Victor G.\} and Satoru Hosomi and Vlasov, \{Igor I.\} and Cecilia Sahlgren and Rosenholm, \{Jessica M.\}",

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doi = "10.1039/c3nr33926b",

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Prabhakar, N, Näreoja, T, von Haartman, E, Sen Karaman, D, Jiang, H, Koho, S, [Unknown], TAD, Hänninen, PE, Vlasov, DI, Ralchenko, VG, Hosomi, S, Vlasov, II, Sahlgren, C & Rosenholm, JM 2013, 'Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application', Nanoscale, vol. 5, no. 9, pp. 3713–3722. https://doi.org/10.1039/c3nr33926b

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T1 - Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application

AU - Prabhakar, Neeraj

AU - Näreoja, Tuomas

AU - von Haartman, Eva

AU - Sen Karaman, Didem

AU - Jiang, Hua

AU - Koho, Sami

AU - [Unknown], Tatians A.Dolenko

AU - Hänninen, Pekka E.

AU - Vlasov, Denis I.

AU - Ralchenko, Victor G.

AU - Hosomi, Satoru

AU - Vlasov, Igor I.

AU - Sahlgren, Cecilia

AU - Rosenholm, Jessica M.

PY - 2013

Y1 - 2013

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AB - Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.

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DO - 10.1039/c3nr33926b

M3 - Artikel

SN - 2040-3364

VL - 5

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EP - 3722

JO - Nanoscale

JF - Nanoscale

IS - 9

ER -

Core--shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application

Abstract

Funding

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Projects

Targeting Notch signalign in cancer

Cite this