Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst: Bed dilution effects and cinchonidine adsorption study

E. Toukoniitty; P. Mäki-Arvela; N. Kumar; T. Salmi; D. Yu Murzin

doi:10.1023/B:CATL.0000027292.23132.5c

Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al₂O₃ catalyst: Bed dilution effects and cinchonidine adsorption study

E. Toukoniitty
, P. Mäki-Arvela
, N. Kumar
, T. Salmi
, D. Yu Murzin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

28 Citations (Scopus)

Abstract

Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al₂O₃, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Catalysis Letters
Volume	95
Issue number	3-4
DOIs	https://doi.org/10.1023/B:CATL.0000027292.23132.5c
Publication status	Published - Jun 2004
MoE publication type	A1 Journal article-refereed

Keywords

Adsorption of cinchonidine
Bed dilution
Continuous hydrogenation

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10.1023/B:CATL.0000027292.23132.5c

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title = "Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst: Bed dilution effects and cinchonidine adsorption study",

abstract = "Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93\% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.",

keywords = "Adsorption of cinchonidine, Bed dilution, Continuous hydrogenation",

author = "E. Toukoniitty and P. M{\"a}ki-Arvela and N. Kumar and T. Salmi and Murzin, \{D. Yu\}",

year = "2004",

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doi = "10.1023/B:CATL.0000027292.23132.5c",

language = "English",

volume = "95",

pages = "179--183",

journal = "Catalysis Letters",

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T1 - Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst

T2 - Bed dilution effects and cinchonidine adsorption study

AU - Toukoniitty, E.

AU - Mäki-Arvela, P.

AU - Kumar, N.

AU - Salmi, T.

AU - Murzin, D. Yu

PY - 2004/6

Y1 - 2004/6

N2 - Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

AB - Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

KW - Adsorption of cinchonidine

KW - Bed dilution

KW - Continuous hydrogenation

UR - https://www.scopus.com/pages/publications/3543073977

U2 - 10.1023/B:CATL.0000027292.23132.5c

DO - 10.1023/B:CATL.0000027292.23132.5c

M3 - Article

AN - SCOPUS:3543073977

SN - 1011-372X

VL - 95

SP - 179

EP - 183

JO - Catalysis Letters

JF - Catalysis Letters

IS - 3-4

ER -

Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al₂O₃ catalyst: Bed dilution effects and cinchonidine adsorption study

Abstract

Keywords

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