Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.
|Number of pages||5|
|Publication status||Published - Jun 2004|
|MoE publication type||A1 Journal article-refereed|
- Adsorption of cinchonidine
- Bed dilution
- Continuous hydrogenation