Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al2O3 catalyst: Bed dilution effects and cinchonidine adsorption study

E. Toukoniitty, P. Mäki-Arvela, N. Kumar, T. Salmi, D. Yu Murzin*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

24 Citations (Scopus)

Abstract

Depending on the reaction medium (toluene or acetic acid) striking differences were observed in the development of enantiomeric excess with time-on-stream in continuous enantioselective hydrogenation of ethylbenzoylformate on cinchonidine-modified Pt/Al2O3, which correlated well with the amount of adsorbed cinchonidine on alumina and silica from acetic acid and toluene solutions. Maximally 93% enantiometric excess (ee) of (R)-ethyl mandelate was obtained.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalCatalysis Letters
Volume95
Issue number3-4
DOIs
Publication statusPublished - Jun 2004
MoE publication typeA1 Journal article-refereed

Keywords

  • Adsorption of cinchonidine
  • Bed dilution
  • Continuous hydrogenation

Fingerprint Dive into the research topics of 'Continuous enantioselective hydrogenation of ethylbenzoylformate over Pt/Al<sub>2</sub>O<sub>3</sub> catalyst: Bed dilution effects and cinchonidine adsorption study'. Together they form a unique fingerprint.

Cite this