Comparative safety evaluation of silica-based particles

H Kettiger; Didem Sen Karaman; L Schiesser; Jessica Rosenholm; J Huwyler

doi:10.1016/j.tiv.2015.09.030

Comparative safety evaluation of silica-based particles

H Kettiger, Didem Sen Karaman, L Schiesser, Jessica Rosenholm, J Huwyler

Pharmacy

Research output: Contribution to journal › Article › Scientific › peer-review

31 Citations (Scopus)

Abstract

Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.

Original language	Undefined/Unknown
Pages (from-to)	355–363
Journal	Toxicology in Vitro
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.tiv.2015.09.030
Publication status	Published - 2015
MoE publication type	A1 Journal article-refereed

Access to Document

10.1016/j.tiv.2015.09.030

http://www.sciencedirect.com/science/article/pii/S0887233315002507

Cite this

@article{ab6c5fcce0aa4dc8b847762d721e5bb5,

title = "Comparative safety evaluation of silica-based particles",

abstract = "Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.",

author = "H Kettiger and {Sen Karaman}, Didem and L Schiesser and Jessica Rosenholm and J Huwyler",

year = "2015",

doi = "10.1016/j.tiv.2015.09.030",

language = "Odefinierat/ok{\"a}nt",

volume = "30",

pages = "355–363",

journal = "Toxicology in Vitro",

issn = "0887-2333",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Comparative safety evaluation of silica-based particles

AU - Kettiger, H

AU - Sen Karaman, Didem

AU - Schiesser, L

AU - Rosenholm, Jessica

AU - Huwyler, J

PY - 2015

Y1 - 2015

N2 - Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.

AB - Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.

U2 - 10.1016/j.tiv.2015.09.030

DO - 10.1016/j.tiv.2015.09.030

M3 - Artikel

SN - 0887-2333

VL - 30

SP - 355

EP - 363

JO - Toxicology in Vitro

JF - Toxicology in Vitro

IS - 1

ER -