Comparative safety evaluation of silica-based particles

H Kettiger, Didem Sen Karaman, L Schiesser, Jessica Rosenholm, J Huwyler

Research output: Contribution to journalArticleScientificpeer-review

25 Citations (Scopus)

Abstract

Silica nanoparticles (SNPs) are increasingly used as drug delivery systems (DDS) and for biomedical imaging. Therapeutic and diagnostic agents can be incorporated into the silica matrix to improve the stability and dissolution of drug substances in biological systems. However, the safety of SNPs as drug carriers remains controversial. To date, no validated and accepted nano-specific tests exist to predict the potentially harmful impact of these materials on the human body.
Original languageUndefined/Unknown
Pages (from-to)355–363
JournalToxicology in Vitro
Volume30
Issue number1
DOIs
Publication statusPublished - 2015
MoE publication typeA1 Journal article-refereed

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