Cognitive Decline and Amyloid Accumulation in Patients with Mild Cognitive Impairment

J Koivunen, Mira Karrasch, NM Scheinin, S Aalto, T Vahlberg, K Någren, S Helin, M Viitanen, JO Rinne

    Research output: Contribution to journalArticleScientificpeer-review

    10 Citations (Scopus)

    Abstract

    Background/Aims: The relationship between baseline 11C-Pittsburgh compound B (C-11-PIB) uptake and cognitive decline during a 2-year follow-up was studied in 9 patients with mild cognitive impairment (MCI) who converted to Alzheimer's disease (AD) and 7 who remained with MCI. Methods: 11C-PIB PET scan was conducted at baseline and cognitive assessment both at baseline and at follow-up. To obtain quantitative regional values of 11C-PIB uptake, automated region of interest analysis was done using spatially normalized parametric ratio (region-to-cerebellar cortex) images. Results: At baseline, there were statistically significant differences in 11C-PIB uptake, but not in cognitive test performances between the converters and nonconverters. Memory and executive function declined only in the converters during follow-up. In the converters, lower baseline frontal 11C-PIB uptake was associated with faster decline in verbal learning. Higher baseline uptake in the caudate nucleus was related to faster decline in memory consolidation, and higher temporal uptake was associated with decline in executive function. Conclusion: Higher 11C-PIB uptake in the caudate nucleus and temporal lobe was related to decline in memory and executive functions, whereas lower frontal uptake was related to decline in verbal learning. The results indicate that in prodromal AD, frontal amyloid accumulation reaches its maximum in the MCI stage, characterized by memory problems without full-blown dementia. Copyright (C) 2012 S. Karger AG, Basel
    Original languageUndefined/Unknown
    Pages (from-to)31–37
    Number of pages7
    JournalDementia and Geriatric Cognitive Disorders
    Volume34
    Issue number1
    DOIs
    Publication statusPublished - 2012
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Alzheimer's disease
    • Cognition
    • Episodic memory
    • Mild cognitive impairment
    • Pittsburgh compound B
    • Psychometric tests

    Cite this